Tchem TRPM6 Transient receptor potential cation channel subfamily M member 6

Protein Summary

Description

Essential ion channel and serine/threonine-protein kinase. Crucial for magnesium homeostasis. Has an important role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel region. This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]

Uniprot Accession IDs

• Q9BX84
• Q6VPR8
• Q6VPR9
• Q6VPS0
• Q6VPS1
• Q6VPS2

Gene Name

• TRPM6

Ensembl ID

• ENST00000360774
• ENSP00000354006
• ENSG00000119121
• ENST00000361255
• ENSP00000354962
• ENST00000449912
• ENSP00000396672

Symbol

• CHAK2
• HSH
• HMGX
• HOMG
• CHAK2
• HOMG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
cell type or tissue	0.66
tissue	0.61
virus perturbation	0.59
cell line	0.58

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Transient Receptor Potential Cation Channel Subfamily M Member 6

Protein / Receptor / Transient Receptor Potential Cation Channel Subfamily M Member 6

DTO Classes

Protein / Kinase / Protein Kinase / Atypical Group / Alpha Family / Chak Subfamily / Transient Receptor Potential Cation Channel Subfamily M Member 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.15   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 122   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.15   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0