Tchem TRPC3 Short transient receptor potential channel 3

Protein Summary

Description

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q13507
• A7VJS1
• E9PCJ9
• O00593
• Q15660
• Q52M35
• Q5G1L5
• TrpC3

Gene Name

• TRPC3

Ensembl ID

• ENST00000264811
• ENSP00000264811
• ENSG00000138741
• ENST00000379645
• ENSP00000368966

Symbol

• TRP3
• TRP3
• SCA41

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
molecular function	0.9
hub protein	0.82
metabolite	0.82
biological process	0.72

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Short Transient Receptor Potential Channel 3

DTO Classes

Protein / Ion Channel / Transient Receptor Potential Calcium Channel (Trp-cc) Family / Strpc Subfamily / Trpc3 Sub-subfamily / Short Transient Receptor Potential Channel 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 394.53   (req: < 5)

Gene RIFs: 90   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 394.53   (req: >= 5)

Gene RIFs: 90   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 34

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (2)

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1 – 2 of 2

clemizole

TRPC3Tchem IC

BLOCKER pIC50 : 5.89

norgestimate

TRPC3Tchem IC

BLOCKER pIC50 : 5.28

Active Ligands (34)

Explore Active Ligands

1 – 10 of 34

Gd³⁺

TRPC3Tchem IC

pEC50 : 7

2-APB

TRPC3Tchem IC

pIC50 : 6.1

CHEMBL2418806

TRPC3Tchem IC

pIC50 : 7.1

GSK2833503A

TRPC3Tchem IC

pIC50 : 8.52

BTP2

TRPC3Tchem IC

pEC50 : 8.1

pyrazolopyrimidine 4n

TRPC3Tchem IC

pEC50 : 7.72

La³⁺

TRPC3Tchem IC

: 5.4

SAR7334

TRPC3Tchem IC

pIC50 : 8.1

SH045

TRPC3Tchem IC

pIC50 : 7.2

GSK1702934A

TRPC3Tchem IC

pEC50 : 7.1

Protein-Protein Interactions (99)

Explore Interacting Targets

1 – 10 of 99

• See Interactions on String-DB

TRPC7

Tchem

Family:  IC

Novelty:  0.0033307

p_int:  0.999957691

p_wrong:  0.000042309

Score:  0.93

Data Source:  BioPlex,STRINGDB

SEC24B

Tbio

Novelty:  0.01031644

p_int:  0.985334924

p_ni:  0.014665076

Data Source:  BioPlex

SELENOO

Tdark

Novelty:  0.02959704

p_int:  0.945241063

p_ni:  0.05296821

p_wrong:  0.001790726

Data Source:  BioPlex

SEC24A

Tbio

Novelty:  0.07724534

p_int:  0.93393751

p_ni:  0.06606249

Data Source:  BioPlex

USP33

Tbio

Family:  Enzyme

Novelty:  0.04411285

p_int:  0.922942459

p_ni:  0.077044193

p_wrong:  0.000013348

Data Source:  BioPlex

RNF181

Tbio

Family:  Enzyme

Novelty:  0.27482636

p_int:  0.908715654

p_ni:  0.089286319

p_wrong:  0.001998027

Data Source:  BioPlex

PDLIM7

Tbio

Novelty:  0.00544518

p_int:  0.860434452

p_ni:  0.139563222

p_wrong:  0.000002326

Data Source:  BioPlex

PLCG1

Tchem

Family:  Enzyme

Novelty:  0.00110273

Score:  0.96

Data Source:  STRINGDB

TRPC1

Tbio

Family:  IC

Novelty:  0.00233677

Score:  0.947

Data Source:  Reactome,STRINGDB

TRPC4

Tchem

Family:  IC

Novelty:  0.00339889

Score:  0.942

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (275)

Reactome (23)

KEGG (1)

PathwayCommons (1)

WikiPathways (250)

Axon guidance (R-HSA-422475)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Effects of PIP2 hydrolysis	27 targets	R-HSA-114508
Reactome	Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853
Reactome	G alpha (q) signalling events	219 targets	R-HSA-416476

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
Effects of PIP2 hydrolysis	27 targets	R-HSA-114508
Elevation of cytosolic Ca2+ levels	16 targets	R-HSA-139853
G alpha (q) signalling events	219 targets	R-HSA-416476

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (17)

Functions (3)

Components (3)

Processes (11)

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1 – 3 of 3

GO Term	Evidence	Assigned by
inositol 1,4,5 trisphosphate binding	Inferred from Direct Assay (IDA)	BHF-UCL
store-operated calcium channel activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium channel activity	Traceable Author Statement (TAS)	Reactome

Disease Associations ()

No disease associations found

GWAS Traits (6)

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1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	2	2	2		93.8
mean corpuscular volume	EFO_0004526	2	2	2		87.2
mean reticulocyte volume	EFO_0010701	1	1	1		85.1
psoriasis	EFO_0000676	1	1	1		71.5
BMI-adjusted hip circumference	EFO_0008039	1	3	3		66.3

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular hemoglobin concentration	EFO_0004528	2		93.8
mean corpuscular volume	EFO_0004526	2		87.2
mean reticulocyte volume	EFO_0010701	1		85.1
psoriasis	EFO_0000676	1		71.5
BMI-adjusted hip circumference	EFO_0008039	3		66.3

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
ANK repeat
Calcium
Calcium channel
Calcium transport
Complete proteome
Disease mutation
Glycoprotein
Ion channel

GWAS Trait Find Similar Targets

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BMI-adjusted hip circumference
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean reticulocyte volume
psoriasis
red blood cell density measurement

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
growth/size/body region phenotype
mortality/aging
nervous system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transient receptor potential cation channel subfamily C member 3	VGNC:7428	471294
Macaque	transient receptor potential cation channel subfamily C member 3		707586
Mouse	transient receptor potential cation channel, subfamily C, member 3	MGI:109526	22065
Rat	transient receptor potential cation channel, subfamily C, member 3	RGD:61973	60395
Dog	transient receptor potential cation channel subfamily C member 3	VGNC:47867	483844

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transient receptor potential cation channel subfamily C member 3
Macaque	transient receptor potential cation channel subfamily C member 3
Mouse	transient receptor potential cation channel, subfamily C, member 3
Rat	transient receptor potential cation channel, subfamily C, member 3
Dog	transient receptor potential cation channel subfamily C member 3

Publication Statistics

PubMed Score 394.53

PubMed score by year

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PubTator Score 229.74

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Patents

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Related Publications

Text Mined References (118)

GeneRif Annotations (90)

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PMID	Year	Title