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Tclin
TRPA1
Transient receptor potential cation channel subfamily A member 1

Protein Summary
Description
Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity). The structure of the protein encoded by this gene is highly related to both the protein ankyrin and tra ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262209
  • ENSP00000262209
  • ENSG00000104321

Symbol
  • ANKTM1
  • FEPS
  • FEPS1
  • ANKTM1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
chemical
0.84
biological term
0.8
histone modification site profile
0.64
cell line
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1389.63   (req: < 5)
Gene RIFs: 137   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1389.63   (req: >= 5)
Gene RIFs: 137   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 577
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (113)
TRPV1
Tclin
Family:  IC
Novelty:  0.00039493
Score:  0.963
Data Source:  STRINGDB
TRPM8
Tclin
Family:  IC
Novelty:  0.00153949
Score:  0.944
Data Source:  STRINGDB
TRPV2
Tchem
Family:  IC
Novelty:  0.00472952
Score:  0.889
Data Source:  STRINGDB
PRKCE
Tchem
Family:  Kinase
Novelty:  0.00890161
Score:  0.885
Data Source:  STRINGDB
TPRA1
Tdark
Family:  GPCR
Novelty:  0.16743826
Score:  0.804
Data Source:  STRINGDB
NGF
Tchem
Novelty:  0.00008139
Score:  0.785
Data Source:  STRINGDB
TRPM3
Tchem
Family:  IC
Novelty:  0.00647452
Score:  0.777
Data Source:  STRINGDB
TRPM7
Tchem
Family:  IC
Novelty:  0.00265096
Score:  0.74
Data Source:  STRINGDB
SCN10A
Tclin
Family:  IC
Novelty:  0.00107685
Score:  0.735
Data Source:  STRINGDB
TRPC3
Tchem
Family:  IC
Novelty:  0.00268752
Score:  0.734
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
80.6
1
1
0
1.1
55.2
lymphocyte percentage of leukocytes
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
80.6
0
1.1
55.2
lymphocyte percentage of leukocytes
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily A member 1
VGNC:7602
464230
Macaque
transient receptor potential cation channel subfamily A member 1
694623
Mouse
MGI:3522699
277328
Rat
RGD:1303284
312896
Dog
transient receptor potential cation channel subfamily A member 1
VGNC:47865
486994
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transient receptor potential cation channel subfamily A member 1
Macaque
transient receptor potential cation channel subfamily A member 1
Mouse
Rat
Dog
transient receptor potential cation channel subfamily A member 1
Publication Statistics
PubMed Score 1389.63
PubMed score by year
PubTator Score 508.34
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title