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Tbio
TRO
Trophinin

Protein Summary
Description
Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion. This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000173898
  • ENSP00000173898
  • ENSG00000067445
  • ENST00000319167
  • ENSP00000318278
  • ENST00000375022
  • ENSP00000364162
  • ENST00000375041
  • ENSP00000364181
  • ENST00000399736
  • ENSP00000382641
  • ENST00000420798
  • ENSP00000405126

Symbol
  • KIAA1114
  • MAGED3
  • MAGED3
  • MAGE-d3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
tissue sample
0.69
transcription factor perturbation
0.68
cellular component
0.58
disease perturbation
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.44   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 53   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.44   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0