You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TRMT61A
tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A

Protein Summary
Description
Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Catalytic subunit of mRNA N(1)-methyltransferase complex, which mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389749
  • ENSP00000374399
  • ENSG00000166166

Symbol
  • C14orf172
  • TRM61
  • GCD14
  • TRM61
  • Gcd14p
  • hTRM61
  • C14orf172
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
virus perturbation
0.76
histone modification site profile
0.75
cell type or tissue
0.72
transcription factor binding site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.92   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.92   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0