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Tbio
TRMT6
tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6

Protein Summary
Description
Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries (PubMed:29107537, PubMed:29072297). This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript var ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000203001
  • ENSP00000203001
  • ENSG00000089195
  • ENST00000453074
  • ENSP00000392070

Symbol
  • KIAA1153
  • TRM6
  • GCD10
  • CGI-09
  • Gcd10p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
histone modification site profile
0.9
interacting protein
0.9
virus perturbation
0.83
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.23   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.23   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (254)
TRMT61A
Tbio
Family:  Enzyme
Novelty:  0.04443394
p_int:  0.999999992
p_ni:  4e-9
p_wrong:  5e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999417576
p_ni:  0.000582424
Score:  0.234
Data Source:  BioPlex,STRINGDB
PPARD
Tchem
Family:  NR
Novelty:  0.00271873
p_int:  0.994272102
p_ni:  0.005727898
Score:  0.228
Data Source:  BioPlex,STRINGDB
LAMTOR5
Tbio
Novelty:  0.003692
p_int:  0.993973279
p_ni:  0.00602672
p_wrong:  1e-9
Data Source:  BioPlex
KLHL22
Tbio
Novelty:  0.24456252
p_int:  0.992128321
p_ni:  0.00787167
p_wrong:  8e-9
Data Source:  BioPlex
LRRC8E
Tbio
Novelty:  0.15689344
p_int:  0.986323895
p_ni:  0.013676103
p_wrong:  2e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
SRP9
Tbio
Novelty:  0.02243103
p_int:  0.982502155
p_ni:  0.017497843
p_wrong:  2e-9
Score:  0.775
Data Source:  BioPlex,STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.970554914
p_ni:  0.029445086
Score:  0.166
Data Source:  BioPlex,STRINGDB
ACAA1
Tbio
Family:  Enzyme
Novelty:  0.00710465
p_int:  0.968875283
p_ni:  0.031123949
p_wrong:  7.68e-7
Data Source:  BioPlex
CBWD1
Tbio
Novelty:  0.04321511
p_int:  0.916768802
p_ni:  0.083231028
p_wrong:  1.7e-7
Score:  0.178
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
4
3
5
97.2
1
1
0
1.2
42.3
anti-Mullerian hormone measurement
1
1
1
39.6
Menorrhagia
1
1
0
1.2
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
5
97.2
0
1.2
42.3
anti-Mullerian hormone measurement
1
39.6
Menorrhagia
0
1.2
17.8
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 6
VGNC:6289
747713
Macaque
tRNA methyltransferase 6
718229
Mouse
MGI:1914176
66926
Rat
RGD:1308877
311441
Dog
tRNA methyltransferase 6
VGNC:54738
485777
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 6
Macaque
tRNA methyltransferase 6
Mouse
Rat
Dog
tRNA methyltransferase 6
Publication Statistics
PubMed Score 16.23
PubMed score by year
PubTator Score 3.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title