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Tbio
TRMT2A
tRNA (uracil-5-)-methyltransferase homolog A

Protein Summary
Description
May be involved in nucleic acid metabolism and/or modifications. The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252136
  • ENSP00000252136
  • ENSG00000099899
  • ENST00000403707
  • ENSP00000385807
  • ENST00000404751
  • ENSP00000384968

Symbol
  • HTF9C
  • HTF9C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.93
interacting protein
0.78
histone modification site profile
0.77
transcription factor
0.71
small molecule perturbation
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.34   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.34   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (175)
SMARCAD1
Tbio
Novelty:  0.04117162
p_int:  0.999985416
p_ni:  0.000014584
Score:  0.179
Data Source:  BioPlex,STRINGDB
ANKRD44
Tdark
Family:  Enzyme
Novelty:  0.38360979
p_int:  0.999884805
p_ni:  0.000115193
p_wrong:  2e-9
Score:  0.791
Data Source:  BioPlex,STRINGDB
PBK
Tchem
Family:  Kinase
Novelty:  0.00278659
p_int:  0.9995626
p_ni:  0.000437397
p_wrong:  4e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
PPP6R2
Tbio
Family:  Enzyme
Novelty:  0.12886225
p_int:  0.9993069
p_ni:  0.0006931
Score:  0.254
Data Source:  BioPlex,STRINGDB
ANKRD52
Tbio
Family:  Enzyme
Novelty:  0.14147652
p_int:  0.999145534
p_ni:  0.000854466
Score:  0.187
Data Source:  BioPlex,STRINGDB
ATP5S
Tbio
Family:  Enzyme
Novelty:  0.15637839
p_int:  0.999142624
p_ni:  0.000036251
p_wrong:  0.000821124
Score:  0.19
Data Source:  BioPlex,STRINGDB
ANKHD1
Tbio
Novelty:  0.05390096
p_int:  0.998946757
p_ni:  0.001053243
Data Source:  BioPlex
FEZ2
Tbio
Novelty:  0.1716508
p_int:  0.998639759
p_ni:  0.00054441
p_wrong:  0.000815831
Score:  0.175
Data Source:  BioPlex,STRINGDB
ANKRD28
Tbio
Family:  Enzyme
Novelty:  0.10895759
p_int:  0.997939704
p_ni:  0.002060296
Score:  0.322
Data Source:  BioPlex,STRINGDB
TARBP2
Tbio
Novelty:  0.01485994
p_int:  0.994365404
p_ni:  0.005634596
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
Name
Explore in Pharos
Explore in Source
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
68.8
serum metabolite measurement
1
1
1
57.8
platelet crit
1
1
1
52.7
intraocular pressure measurement
1
1
1
35
smoking status measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
68.8
serum metabolite measurement
1
57.8
platelet crit
1
52.7
intraocular pressure measurement
1
35
smoking status measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 2 homolog A
VGNC:5987
458660
Macaque
tRNA methyltransferase 2 homolog A
719425
Mouse
MGI:96270
15547
Rat
RGD:1310418
287953
Dog
tRNA methyltransferase 2 homolog A
VGNC:47858
477564
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 2 homolog A
Macaque
tRNA methyltransferase 2 homolog A
Mouse
Rat
Dog
tRNA methyltransferase 2 homolog A
Publication Statistics
PubMed Score 7.34
PubMed score by year
PubTator Score 1.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title