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Tdark
TRMT13
tRNA:m(4)X modification enzyme TRM13 homolog

Protein Summary
Description
tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370141
  • ENSP00000359160
  • ENSG00000122435
  • ENST00000482437
  • ENSP00000432616

Symbol
  • CCDC76
  • CCDC76
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
cellular component
0.64
tissue sample
0.64
transcription factor perturbation
0.61
transcription factor binding site profile
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.76   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.76   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
STAG1
Tbio
Novelty:  0.00122511
p_int:  0.998637963
p_ni:  0.000494664
p_wrong:  0.000867373
Score:  0.305
Data Source:  BioPlex,STRINGDB
AGO1
Tbio
Novelty:  0.00157424
p_int:  0.996574534
p_ni:  0.003393883
p_wrong:  0.000031584
Data Source:  BioPlex
OSER1
Tbio
Novelty:  0.21052793
p_int:  0.820940853
p_ni:  0.000512059
p_wrong:  0.178547088
Score:  0.359
Data Source:  BioPlex,STRINGDB
SAYSD1
Tdark
Novelty:  0.62764863
Score:  0.767
Data Source:  STRINGDB
C5orf22
Tdark
Novelty:  1.29325352
Score:  0.753
Data Source:  STRINGDB
TPGS2
Tdark
Family:  Enzyme
Novelty:  0.45018261
Score:  0.749
Data Source:  STRINGDB
CHAMP1
Tbio
Novelty:  0.09520274
Score:  0.667
Data Source:  STRINGDB
PIGH
Tbio
Family:  Enzyme
Novelty:  0.0584561
Score:  0.667
Data Source:  STRINGDB
LRRC8B
Tbio
Novelty:  0.16457267
Score:  0.66
Data Source:  STRINGDB
NXT2
Tdark
Novelty:  0.03767394
Score:  0.655
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leucine measurement
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leucine measurement
1
15.1
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 13 homolog
VGNC:9423
742372
Macaque
tRNA methyltransferase 13 homolog
711396
Mouse
MGI:1925219
229780
Rat
RGD:1565211
499697
Dog
tRNA methyltransferase 13 homolog
VGNC:54082
479930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 13 homolog
Macaque
tRNA methyltransferase 13 homolog
Mouse
Rat
Dog
tRNA methyltransferase 13 homolog
Publication Statistics
PubMed Score 0.76
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title