Tdark TRMT10B tRNA methyltransferase 10 homolog B

Protein Summary

Description

S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).

Uniprot Accession IDs

• Q6PF06
• B7Z216
• B7Z3D3
• Q05DJ4
• Q5QP83
• Q8NAG2
• Q96N36

Gene Name

• TRMT10B

Ensembl ID

• ENST00000297994
• ENSP00000297994
• ENSG00000165275
• ENST00000377753
• ENSP00000366982
• ENST00000377754
• ENSP00000366983
• ENST00000488673
• ENSP00000437395
• ENST00000537911
• ENSP00000444997

Symbol

• RG9MTD3
• RG9MTD3
• bA3J10.9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.86
cellular component	0.75
tissue	0.59
tissue sample	0.58
microRNA	0.54

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Dna Methyltransferase / Trna Methyltransferase 10 Homolog B

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Methyltransferase / Trna Methyltransferase 10 Homolog B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.27   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.27   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (78)

Explore Interacting Targets

1 – 10 of 78

• See Interactions on String-DB

TUBA8

Tbio

Novelty:  0.06454549

p_int:  0.999962044

p_ni:  0.000037955

p_wrong:  1e-9

Score:  0.152

Data Source:  BioPlex,STRINGDB

NOA1

Tbio

Novelty:  0.01478325

p_int:  0.998992763

p_ni:  0.001007236

Score:  0.713

Data Source:  BioPlex,STRINGDB

MRPS33

Tdark

Novelty:  0.27300643

p_int:  0.997724292

p_ni:  0.002275708

Score:  0.745

Data Source:  BioPlex,STRINGDB

MRPS35

Tdark

Novelty:  6.44240335

p_int:  0.997277311

p_ni:  0.002722689

Score:  0.594

Data Source:  BioPlex,STRINGDB

PTX3

Tbio

Novelty:  0.00153752

p_int:  0.997227089

p_ni:  0.000978155

p_wrong:  0.001794756

Score:  0.181

Data Source:  BioPlex,STRINGDB

MRPS5

Tbio

Novelty:  0.11423336

p_int:  0.990253533

p_ni:  0.009746467

Score:  0.718

Data Source:  BioPlex,STRINGDB

MRPS18C

Tdark

Novelty:  0.42868428

p_int:  0.989705158

p_ni:  0.010294687

p_wrong:  1.54e-7

Score:  0.585

Data Source:  BioPlex,STRINGDB

PTCD3

Tbio

Novelty:  0.12368434

p_int:  0.989082475

p_ni:  0.010917525

Score:  0.656

Data Source:  BioPlex,STRINGDB

MRPS9

Tdark

Novelty:  0.22906484

p_int:  0.988406127

p_ni:  0.011593873

Score:  0.595

Data Source:  BioPlex,STRINGDB

MRPS7

Tbio

Novelty:  0.00153134

p_int:  0.988115183

p_ni:  0.011884817

Score:  0.585

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (3)

Components (1)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
tRNA (guanine-N1-)-methyltransferase activity	Inferred from Direct Assay (IDA)	CAFA
tRNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
tRNA (guanine(9)-N(1))-methyltransferase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations (null)

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	2	2	2		47.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
reticulocyte count	EFO_0007986	2		47.5

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Coiled coil
Complete proteome
Methyltransferase
Polymorphism
Reference proteome
S-adenosyl-L-methionine
Transferase

GWAS Trait Find Similar Targets

No Header	No Header
reticulocyte count

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	tRNA methyltransferase 10B	VGNC:13984	473128
Macaque	tRNA methyltransferase 10B		716301
Mouse	tRNA methyltransferase 10B	MGI:1917184	69934
Rat	tRNA methyltransferase 10B	RGD:1310735	298081
Dog	tRNA methyltransferase 10B	VGNC:47852	481615

Species	Name	OMA	EggNOG	Inparanoid
Chimp	tRNA methyltransferase 10B
Macaque	tRNA methyltransferase 10B
Mouse	tRNA methyltransferase 10B
Rat	tRNA methyltransferase 10B
Dog	tRNA methyltransferase 10B

Publication Statistics

PubMed Score 1.27

PubMed score by year

Reset Zoom

Related Publications

Text Mined References (5)

Items per page:

10

0 of 0

PMID	Year	Title