You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TRMT10B
tRNA methyltransferase 10 homolog B

Protein Summary
Description
S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297994
  • ENSP00000297994
  • ENSG00000165275
  • ENST00000377753
  • ENSP00000366982
  • ENST00000377754
  • ENSP00000366983
  • ENST00000488673
  • ENSP00000437395
  • ENST00000537911
  • ENSP00000444997

Symbol
  • RG9MTD3
  • RG9MTD3
  • bA3J10.9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
cellular component
0.75
tissue
0.59
tissue sample
0.58
microRNA
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.27   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.27   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
TUBA8
Tbio
Novelty:  0.06454549
p_int:  0.999962044
p_ni:  0.000037955
p_wrong:  1e-9
Score:  0.152
Data Source:  BioPlex,STRINGDB
NOA1
Tbio
Novelty:  0.01478325
p_int:  0.998992763
p_ni:  0.001007236
Score:  0.713
Data Source:  BioPlex,STRINGDB
MRPS33
Tdark
Novelty:  0.27300643
p_int:  0.997724292
p_ni:  0.002275708
Score:  0.745
Data Source:  BioPlex,STRINGDB
MRPS35
Tdark
Novelty:  6.44240335
p_int:  0.997277311
p_ni:  0.002722689
Score:  0.594
Data Source:  BioPlex,STRINGDB
PTX3
Tbio
Novelty:  0.00153752
p_int:  0.997227089
p_ni:  0.000978155
p_wrong:  0.001794756
Score:  0.181
Data Source:  BioPlex,STRINGDB
MRPS5
Tbio
Novelty:  0.11423336
p_int:  0.990253533
p_ni:  0.009746467
Score:  0.718
Data Source:  BioPlex,STRINGDB
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.989705158
p_ni:  0.010294687
p_wrong:  1.54e-7
Score:  0.585
Data Source:  BioPlex,STRINGDB
PTCD3
Tbio
Novelty:  0.12368434
p_int:  0.989082475
p_ni:  0.010917525
Score:  0.656
Data Source:  BioPlex,STRINGDB
MRPS9
Tdark
Novelty:  0.22906484
p_int:  0.988406127
p_ni:  0.011593873
Score:  0.595
Data Source:  BioPlex,STRINGDB
MRPS7
Tbio
Novelty:  0.00153134
p_int:  0.988115183
p_ni:  0.011884817
Score:  0.585
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
2
2
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
47.5
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 10B
VGNC:13984
473128
Macaque
tRNA methyltransferase 10B
716301
Mouse
MGI:1917184
69934
Rat
RGD:1310735
298081
Dog
tRNA methyltransferase 10B
VGNC:47852
481615
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase 10B
Macaque
tRNA methyltransferase 10B
Mouse
Rat
Dog
tRNA methyltransferase 10B
Publication Statistics
PubMed Score 1.27
PubMed score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title