Tbio TRMO tRNA (adenine(37)-N6)-methyltransferase

Protein Summary

Description

S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity).

Uniprot Accession IDs

• Q9BU70
• Q5T113
• Q86SK0
• Q9NXJ7
• Q9P0Q7

Gene Name

• TRMO

Ensembl ID

• ENST00000375119
• ENSP00000364260
• ENSG00000136932

Symbol

• C9orf156
• NAP1
• HSPC219
• C9orf156

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.94   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 153   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.94   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0