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Tbio
TRMO
tRNA (adenine(37)-N6)-methyltransferase

Protein Summary
Description
S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375119
  • ENSP00000364260
  • ENSG00000136932

Symbol
  • C9orf156
  • NAP1
  • HSPC219
  • C9orf156
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.95   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.95   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
STAT5B
Tchem
Family:  TF
Novelty:  0.00074178
p_int:  0.995094101
p_ni:  0.003802384
p_wrong:  0.001103516
Score:  0.416
Data Source:  BioPlex,STRINGDB
RHPN2
Tbio
Novelty:  0.04808006
p_int:  0.993409906
p_ni:  4.5e-8
p_wrong:  0.006590048
Score:  0.359
Data Source:  BioPlex,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.989850038
p_ni:  0.010024511
p_wrong:  0.000125451
Score:  0.152
Data Source:  BioPlex,STRINGDB
MYH9
Tbio
Novelty:  0.0016488
p_int:  0.987609568
p_ni:  0.003557478
p_wrong:  0.008832953
Score:  0.606
Data Source:  BioPlex,STRINGDB
VPS26B
Tdark
Novelty:  0.25702869
p_int:  0.861627763
p_ni:  0.138372237
Score:  0.187
Data Source:  BioPlex,STRINGDB
GON7
Tdark
Novelty:  0.21994743
Score:  0.766
Data Source:  STRINGDB
SPATC1L
Tbio
Novelty:  0.20384074
Score:  0.695
Data Source:  STRINGDB
TMEM253
Tdark
Novelty:  3.52941176
Score:  0.679
Data Source:  STRINGDB
YRDC
Tdark
Novelty:  0.01240103
Score:  0.651
Data Source:  STRINGDB
HEMGN
Tbio
Novelty:  0.03687801
Score:  0.643
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
2
2
83.8
mean corpuscular hemoglobin concentration
1
1
1
83.1
platelet crit
2
2
2
83
red blood cell density measurement
1
1
1
81.3
hair color
1
1
0
1.1
71.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
2
83.8
mean corpuscular hemoglobin concentration
1
83.1
platelet crit
2
83
red blood cell density measurement
1
81.3
hair color
0
1.1
71.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase O
VGNC:4891
464603
Macaque
tRNA methyltransferase O
715609
Mouse
MGI:1922003
74753
Rat
RGD:1305420
298072
Dog
tRNA methyltransferase O
VGNC:47849
474773
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tRNA methyltransferase O
Macaque
tRNA methyltransferase O
Mouse
Rat
Dog
tRNA methyltransferase O
Publication Statistics
PubMed Score 4.95
PubMed score by year
PubTator Score 1.67
PubTator score by year
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Related Publications
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PMID
Year
Title