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Tbio
TRIP6
Thyroid receptor-interacting protein 6

Protein Summary
Description
Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor. This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000200457
  • ENSP00000200457
  • ENSG00000087077
  • ENST00000417475
  • ENSP00000413817
  • ENST00000437505
  • ENSP00000410736
  • ENST00000619988
  • ENSP00000479865

Symbol
  • OIP1
  • OIP1
  • OIP-1
  • ZRP-1
  • TRIP-6
  • TRIP6i2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
histone modification site profile
0.81
transcription factor perturbation
0.8
biological process
0.79
hub protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.01   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.01   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (150)
AJUBA
Tbio
Novelty:  0.03561829
p_int:  0.999999221
p_ni:  7.78e-7
p_wrong:  1e-9
Score:  0.432
Data Source:  BioPlex,STRINGDB
KLC4
Tdark
Novelty:  0.32552746
p_int:  0.999995551
p_ni:  0.000004446
p_wrong:  2e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
IGFBP1
Tchem
Novelty:  0.0006975
p_int:  0.999994325
p_ni:  0.000005675
Data Source:  BioPlex
EFL1
Tbio
Novelty:  0.1323879
p_int:  0.999991108
p_ni:  0.000008891
p_wrong:  1e-9
Score:  0.198
Data Source:  BioPlex,STRINGDB
WTIP
Tbio
Novelty:  0.03985563
p_int:  0.999980142
p_ni:  1.2e-8
p_wrong:  0.000019846
Score:  0.478
Data Source:  BioPlex,STRINGDB
KLC1
Tbio
Novelty:  0.00653484
p_int:  0.999978151
p_ni:  0.000021849
Score:  0.562
Data Source:  BioPlex,STRINGDB
KIF5A
Tbio
Novelty:  0.01277095
p_int:  0.999777989
p_ni:  0.00022201
p_wrong:  1e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
CDPF1
Tdark
Novelty:  0.85714286
p_int:  0.999287358
p_ni:  0.000712642
Data Source:  BioPlex
KIF5C
Tbio
Novelty:  0.0238573
p_int:  0.999217258
p_ni:  0.000782742
Score:  0.241
Data Source:  BioPlex,STRINGDB
SAFB2
Tbio
Novelty:  0.12354864
p_int:  0.998648108
p_ni:  0.001351892
Score:  0.16
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
9
3
8
8.6
94
hair color
1
3
0
1.1
92.5
heart rate response to recovery post exercise
5
2
5
92.4
heart rate response to exercise
2
2
2
84.7
alkaline phosphatase measurement
2
2
1
6.8
78.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
8
8.6
94
hair color
0
1.1
92.5
heart rate response to recovery post exercise
5
92.4
heart rate response to exercise
2
84.7
alkaline phosphatase measurement
1
6.8
78.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
thyroid hormone receptor interactor 6
106997578
Mouse
MGI:1343458
22051
Dog
thyroid hormone receptor interactor 6
VGNC:54081
479732
Horse
thyroid hormone receptor interactor 6
VGNC:51256
100069114
Cow
thyroid hormone receptor interactor 6
615869
Species
Name
OMA
EggNOG
Inparanoid
Macaque
thyroid hormone receptor interactor 6
Mouse
Dog
thyroid hormone receptor interactor 6
Horse
thyroid hormone receptor interactor 6
Cow
thyroid hormone receptor interactor 6
Publication Statistics
PubMed Score 63.01
PubMed score by year
PubTator Score 28.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title