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Tbio
TRIP4
Activating signal cointegrator 1

Protein Summary
Description
Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347). May play a role in the development of neuromuscular junction (PubMed:26924529). May play a role in late myogenic differentiation (By similarity). This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with trans ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261884
  • ENSP00000261884
  • ENSG00000103671

Symbol
  • ASC1
  • ASC-1
  • MDCDC
  • SMABF1
  • ZC2HC5
  • HsT17391
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.95
transcription factor binding site profile
0.9
disease perturbation
0.87
molecular function
0.76
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.78   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.78   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
ASCC1
Tbio
Novelty:  0.1280098
p_int:  0.99999999
p_ni:  2e-9
p_wrong:  9e-9
Score:  0.964
Data Source:  BioPlex,STRINGDB
ASCC2
Tbio
Novelty:  0.12261896
p_int:  0.999999967
p_ni:  4e-9
p_wrong:  2.9e-8
Score:  0.994
Data Source:  BioPlex,STRINGDB
ALKBH3
Tchem
Family:  Enzyme
Novelty:  0.02040675
p_int:  0.999958215
p_ni:  0.000041198
p_wrong:  5.87e-7
Score:  0.921
Data Source:  BioPlex,STRINGDB
NOG
Tbio
Novelty:  0.0010373
p_int:  0.999772914
p_ni:  0.000226038
p_wrong:  0.000001048
Data Source:  BioPlex
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.99617764
p_ni:  0.003816143
p_wrong:  0.000006217
Data Source:  BioPlex
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.997
Data Source:  STRINGDB
MED4
Tbio
Family:  Enzyme
Novelty:  0.01200585
Score:  0.994
Data Source:  STRINGDB
MED24
Tbio
Family:  Enzyme
Novelty:  0.05466084
Score:  0.993
Data Source:  STRINGDB
RCOR1
Tbio
Family:  TF
Novelty:  0.00644648
Score:  0.993
Data Source:  STRINGDB
MED13
Tbio
Family:  Enzyme
Novelty:  0.02090708
Score:  0.993
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
2
2
91.7
monocyte count
2
1
2
87
neutrophil count
3
2
3
83.9
leukocyte count
2
2
2
80.5
basophil count
2
1
2
59.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
2
91.7
monocyte count
2
87
neutrophil count
3
83.9
leukocyte count
2
80.5
basophil count
2
59.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor interactor 4
VGNC:1587
453505
Macaque
thyroid hormone receptor interactor 4
707263
Mouse
MGI:1928469
56404
Rat
RGD:1306838
315769
Dog
thyroid hormone receptor interactor 4
VGNC:47847
478340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor interactor 4
Macaque
thyroid hormone receptor interactor 4
Mouse
Rat
Dog
thyroid hormone receptor interactor 4
Publication Statistics
PubMed Score 20.78
PubMed score by year
PubTator Score 12.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title