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Tbio
TRIP13
Pachytene checkpoint protein 2 homolog

Protein Summary
Description
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959). This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. T ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000166345
  • ENSP00000166345
  • ENSG00000071539

Symbol
  • PCH2
  • MVA3
  • 16E1BP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
interacting protein
0.99
small molecule perturbation
0.92
molecular function
0.86
co-expressed gene
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.93   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 191.93   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (259)
MTG1
Tbio
Family:  Enzyme
Novelty:  0.07182539
p_int:  0.999942582
p_ni:  0.000057418
Score:  0.231
Data Source:  BioPlex,STRINGDB
METTL8
Tdark
Family:  Enzyme
Novelty:  0.24190691
p_int:  0.999938432
p_ni:  0.00002273
p_wrong:  0.000038838
Score:  0.265
Data Source:  BioPlex,STRINGDB
PUSL1
Tdark
Family:  Enzyme
Novelty:  2.39739964
p_int:  0.99978115
p_ni:  0.000218841
p_wrong:  8e-9
Score:  0.229
Data Source:  BioPlex,STRINGDB
ADAT3
Tdark
Family:  Enzyme
Novelty:  0.04782001
p_int:  0.986419979
p_ni:  7.41e-7
p_wrong:  0.013579279
Score:  0.324
Data Source:  BioPlex,STRINGDB
CRYZ
Tbio
Family:  Enzyme
Novelty:  0.00168463
p_int:  0.977668623
p_ni:  0.022331377
Score:  0.544
Data Source:  BioPlex,STRINGDB
PI4K2B
Tbio
Family:  Enzyme
Novelty:  0.19272599
p_int:  0.939542766
p_ni:  0.060457234
Score:  0.181
Data Source:  BioPlex,STRINGDB
INTS11
Tbio
Novelty:  0.03333938
p_int:  0.889643711
p_ni:  0.110356289
Score:  0.551
Data Source:  BioPlex,STRINGDB
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.767332672
p_ni:  0.232667328
Score:  0.166
Data Source:  BioPlex,STRINGDB
MAD2L1
Tbio
Novelty:  0.01623659
Score:  0.999
Data Source:  STRINGDB
CDC20
Tbio
Novelty:  0.00197887
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
1
1
8.9
1
1
1
6.1
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
1
8.9
1
6.1
1
6.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor interactor 13
VGNC:4212
100609557
Macaque
thyroid hormone receptor interactor 13
709328
Mouse
MGI:1916966
69716
Rat
RGD:1308516
292206
Dog
thyroid hormone receptor interactor 13
VGNC:47846
609426
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor interactor 13
Macaque
thyroid hormone receptor interactor 13
Mouse
Rat
Dog
thyroid hormone receptor interactor 13
Publication Statistics
PubMed Score 191.93
PubMed score by year
PubTator Score 14.56
PubTator score by year
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Related Publications
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PMID
Year
Title