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Tbio
TRIOBP
TRIO and F-actin-binding protein

Protein Summary
Description
May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000403663
  • ENSP00000386026
  • ENSG00000100106
  • ENST00000406386
  • ENSP00000384312
  • ENST00000407319
  • ENSP00000383913
  • ENST00000644935
  • ENSP00000496394
  • ENST00000646328
  • ENSP00000495322

Symbol
  • KIAA1662
  • TARA
  • TARA
  • TAP68
  • DFNB28
  • dJ37E16.4
  • HRIHFB2122
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
transcription factor perturbation
0.84
transcription factor
0.73
virus perturbation
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.17   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.17   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
VTN
Tbio
Family:  TF
Novelty:  0.00046861
p_int:  0.99999968
p_ni:  3.19e-7
p_wrong:  2e-9
Data Source:  BioPlex
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.999999259
p_ni:  7.4e-7
Data Source:  BioPlex
CORO6
Tdark
Novelty:  0.37416507
p_int:  0.999995265
p_ni:  0.000004733
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.998642465
p_ni:  0.001355815
p_wrong:  0.00000172
Data Source:  BioPlex
ENTHD1
Tdark
Novelty:  5.29427978
p_int:  0.998407668
p_ni:  0.001592195
p_wrong:  1.36e-7
Data Source:  BioPlex
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.997866927
p_ni:  0.002133034
p_wrong:  3.9e-8
Data Source:  BioPlex
PACSIN1
Tbio
Family:  Enzyme
Novelty:  0.01482925
p_int:  0.997340314
p_ni:  0.002656328
p_wrong:  0.000003357
Score:  0.194
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.991583075
p_ni:  0.008416888
p_wrong:  3.6e-8
Data Source:  BioPlex
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.890771825
p_ni:  0.107559713
p_wrong:  0.001668462
Score:  0.549
Data Source:  BioPlex,STRINGDB
FYTTD1
Tbio
Novelty:  0.04600073
p_int:  0.816148041
p_ni:  0.182642381
p_wrong:  0.001209578
Score:  0.169
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
1
3
3
76.5
sex hormone-binding globulin measurement
4
2
4
69.8
cup-to-disc ratio measurement
2
2
2
67.9
intraocular pressure measurement
4
3
5
67.1
basophil count
2
2
2
58.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
76.5
sex hormone-binding globulin measurement
4
69.8
cup-to-disc ratio measurement
2
67.9
intraocular pressure measurement
5
67.1
basophil count
2
58.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TRIO and F-actin binding protein
VGNC:5986
458816
Mouse
MGI:1349410
110253
Rat
RGD:1308485
362956
Dog
TRIO and F-actin binding protein
VGNC:47843
481263
Horse
TRIO and F-actin binding protein [Source:HGNC Symbol;Acc:HGNC:17009]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TRIO and F-actin binding protein
Mouse
Rat
Dog
TRIO and F-actin binding protein
Horse
TRIO and F-actin binding protein [Source:HGNC Symbol;Acc:HGNC:17009]
Publication Statistics
PubMed Score 26.17
PubMed score by year
PubTator Score 145.80
PubTator score by year
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Related Publications
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PMID
Year
Title