TRIO
Triple functional domain protein
Protein Summary
Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases (PubMed:8643598, PubMed:27418539). Involved in coordinating actin remodeling, which is necessary for cell migration and growth (PubMed:10341202). In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses (By similarity). May act as a regulator of adipogenesis (By similarity). This gene encodes a large protein that functions as a GDP to GTP exchange factor. This protein promotes the reorganization of the actin cytoskeleton, thereby playing a role in cell migration and growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
- ENST00000344135
- ENSP00000339291
- ENSG00000038382
- ENST00000344204
- ENSP00000339299
- tgat
- MEBAS
- MRD44
- ARHGEF23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
kinase perturbation | 0.96 | ||
molecular function | 0.96 | ||
transcription factor perturbation | 0.91 | ||
transcription factor binding site profile | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.85 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 50 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.85 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 50 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (215)
ZNF232
Family: TF
Novelty: 0.68288358
p_int: 0.999999971
p_ni: 2.9e-8
Score: 0.238
Data Source: BioPlex,STRINGDB
ZNF785
Family: TF
Novelty: 0.42629766
p_int: 0.999998975
p_ni: 4.2e-8
p_wrong: 9.83e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (86)
Reactome (15)
PathwayCommons (3)
WikiPathways (68)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | DCC mediated attractive signaling | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | Developmental Biology | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Cell death signalling via NRAGE, NRIF and NADE | ||||
DCC mediated attractive signaling | ||||
Death Receptor Signalling | ||||
Developmental Biology | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (4)
Components (1)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
childhood onset asthma | 2 | 1 | 0 | 1.2 | 75.9 | ||||
3 | 1 | 0 | 1.1 | 56.8 | |||||
1 | 1 | 0 | 1.1 | 55.2 | |||||
1 | 1 | 0 | 1.1 | 50.6 | |||||
1 | 1 | 0 | 1.1 | 49.5 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
childhood onset asthma | 0 | 1.2 | 75.9 | ||||
0 | 1.1 | 56.8 | |||||
0 | 1.1 | 55.2 | |||||
0 | 1.1 | 50.6 | |||||
0 | 1.1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | trio Rho guanine nucleotide exchange factor | VGNC:4211 | 461730 | |||||
Mouse | MGI:1927230 | 223435 | ||||||
Rat | RGD:1308360 | 310192 | ||||||
Dog | trio Rho guanine nucleotide exchange factor | VGNC:47842 | 478610 | |||||
Horse | trio Rho guanine nucleotide exchange factor | VGNC:24528 | 100070270 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | trio Rho guanine nucleotide exchange factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | trio Rho guanine nucleotide exchange factor | |||||
Horse | trio Rho guanine nucleotide exchange factor | |||||
Publication Statistics
PubMed Score 26.85
PubMed score by year
PubTator Score 290.90
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (50)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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