TRIO
Triple functional domain protein
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
kinase perturbation | 0.96 | ||
molecular function | 0.96 | ||
transcription factor perturbation | 0.91 | ||
transcription factor binding site profile | 0.9 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Cell death signalling via NRAGE, NRIF and NADE | ||||
Reactome | DCC mediated attractive signaling | ||||
Reactome | Death Receptor Signalling | ||||
Reactome | Developmental Biology | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Cell death signalling via NRAGE, NRIF and NADE | ||||
DCC mediated attractive signaling | ||||
Death Receptor Signalling | ||||
Developmental Biology | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
childhood onset asthma | 2 | 1 | 0 | 1.2 | 75.9 | ||||
3 | 1 | 0 | 1.1 | 56.8 | |||||
1 | 1 | 0 | 1.1 | 55.2 | |||||
1 | 1 | 0 | 1.1 | 50.6 | |||||
1 | 1 | 0 | 1.1 | 49.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
childhood onset asthma | 0 | 1.2 | 75.9 | ||||
0 | 1.1 | 56.8 | |||||
0 | 1.1 | 55.2 | |||||
0 | 1.1 | 50.6 | |||||
0 | 1.1 | 49.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | trio Rho guanine nucleotide exchange factor | VGNC:4211 | 461730 | |||||
Mouse | MGI:1927230 | 223435 | ||||||
Rat | RGD:1308360 | 310192 | ||||||
Dog | trio Rho guanine nucleotide exchange factor | VGNC:47842 | 478610 | |||||
Horse | trio Rho guanine nucleotide exchange factor | VGNC:24528 | 100070270 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | trio Rho guanine nucleotide exchange factor | |||||
Mouse | ||||||
Rat | ||||||
Dog | trio Rho guanine nucleotide exchange factor | |||||
Horse | trio Rho guanine nucleotide exchange factor | |||||
PMID | Year | Title |
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