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Tbio
TRIM68
E3 ubiquitin-protein ligase TRIM68

Protein Summary
Description
Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity. This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300747
  • ENSP00000300747
  • ENSG00000167333

Symbol
  • GC109
  • RNF137
  • SS56
  • SS56
  • GC109
  • SS-56
  • RNF137
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.73
molecular function
0.7
tissue sample
0.69
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.82   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.82   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
PRELP
Tbio
Novelty:  0.02849334
p_int:  0.999999108
p_ni:  8.92e-7
Score:  0.182
Data Source:  BioPlex,STRINGDB
PILRA
Tbio
Novelty:  0.05154386
p_int:  0.999993962
p_ni:  0.000006037
Score:  0.151
Data Source:  BioPlex,STRINGDB
GPC3
Tbio
Novelty:  0.00151823
p_int:  0.999990096
p_ni:  0.000009904
Data Source:  BioPlex
CCK
Tbio
Novelty:  0.00012268
p_int:  0.999948611
p_ni:  0.000051374
p_wrong:  1.5e-8
Data Source:  BioPlex
GCNT2
Tbio
Family:  Enzyme
Novelty:  0.03945461
p_int:  0.999943922
p_ni:  0.000056078
Score:  0.185
Data Source:  BioPlex,STRINGDB
COLQ
Tbio
Family:  Enzyme
Novelty:  0.01414634
p_int:  0.99993354
p_ni:  0.00006646
Data Source:  BioPlex
VEGFB
Tclin
Novelty:  0.00293322
p_int:  0.999911489
p_ni:  0.000088511
Score:  0.163
Data Source:  BioPlex,STRINGDB
NTF4
Tbio
Novelty:  0.00192875
p_int:  0.999861301
p_ni:  0.000138699
Score:  0.309
Data Source:  BioPlex,STRINGDB
CTGF
Tbio
Novelty:  0.0004346
p_int:  0.999817696
p_ni:  0.000182304
Score:  0.185
Data Source:  BioPlex,STRINGDB
CPXM2
Tbio
Family:  Enzyme
Novelty:  0.09967229
p_int:  0.999729533
p_ni:  0.000270467
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
53.3
diastolic blood pressure
1
1
1
44.2
smoking behavior
1
1
1
17.8
monocyte percentage of leukocytes
1
1
1
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
53.3
diastolic blood pressure
1
44.2
smoking behavior
1
17.8
monocyte percentage of leukocytes
1
5.9
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 68
717644
Mouse
MGI:2142077
101700
Dog
tripartite motif containing 68
VGNC:47835
485233
Cow
tripartite motif containing 68
VGNC:36349
538657
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 68
Mouse
Dog
tripartite motif containing 68
Cow
tripartite motif containing 68
Publication Statistics
PubMed Score 9.82
PubMed score by year
PubTator Score 5.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title