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Tbio
TRIM65
Tripartite motif-containing protein 65

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269383
  • ENSP00000269383
  • ENSG00000141569

Symbol
  • 4732463G12Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
cell line
0.72
transcription factor binding site profile
0.68
microRNA
0.64
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.86   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.86   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
CRYL1
Tbio
Family:  Enzyme
Novelty:  0.04513297
p_int:  0.996970524
p_ni:  0.003029435
p_wrong:  4.1e-8
Data Source:  BioPlex
SHARPIN
Tbio
Novelty:  0.0197352
p_int:  0.996054798
p_ni:  0.003934586
p_wrong:  0.000010615
Score:  0.194
Data Source:  BioPlex,STRINGDB
SNX21
Tdark
Novelty:  0.32916633
p_int:  0.995798984
p_ni:  0.004200798
p_wrong:  2.18e-7
Score:  0.159
Data Source:  BioPlex,STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.986417143
p_ni:  0.013545026
p_wrong:  0.000037832
Data Source:  BioPlex
GATD1
Tdark
Family:  Enzyme
Novelty:  0.40291197
p_int:  0.982394485
p_ni:  0.017575326
p_wrong:  0.000030189
Data Source:  BioPlex
DOCK5
Tbio
Novelty:  0.03153692
p_int:  0.926977637
p_ni:  0.072985411
p_wrong:  0.000036952
Data Source:  BioPlex
KDELC1
Tbio
Novelty:  0.10139587
p_int:  0.909876727
p_ni:  0.048571803
p_wrong:  0.041551471
Data Source:  BioPlex
CCNJL
Tdark
Novelty:  2.86306774
p_int:  0.890127616
p_ni:  0.109849131
p_wrong:  0.000023253
Score:  0.198
Data Source:  BioPlex,STRINGDB
HPS5
Tbio
Novelty:  0.05155851
p_int:  0.824449778
p_ni:  0.146515556
p_wrong:  0.029034666
Data Source:  BioPlex
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.772816495
p_ni:  0.008551743
p_wrong:  0.218631762
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
9
5
8
12.5
99.2
low density lipoprotein cholesterol measurement
6
4
6
96.3
sex hormone-binding globulin measurement
8
3
7
6.8
92.3
mean platelet volume
2
2
2
74.5
eosinophil count
3
2
3
69.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
8
12.5
99.2
low density lipoprotein cholesterol measurement
6
96.3
sex hormone-binding globulin measurement
7
6.8
92.3
mean platelet volume
2
74.5
eosinophil count
3
69.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2442815
338364
Rat
RGD:1559497
303684
Dog
tripartite motif containing 65
VGNC:47832
609505
Horse
tripartite motif containing 65
VGNC:24520
100059306
Cow
tripartite motif containing 65
VGNC:36347
618637
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
tripartite motif containing 65
Horse
tripartite motif containing 65
Cow
tripartite motif containing 65
Publication Statistics
PubMed Score 17.86
PubMed score by year
PubTator Score 6.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title