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Tbio
TRIM62
E3 ubiquitin-protein ligase TRIM62

Protein Summary
Description
E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291416
  • ENSP00000291416
  • ENSG00000116525
  • ENST00000543586
  • ENSP00000441173

Symbol
  • DEAR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor binding site profile
0.72
virus perturbation
0.72
tissue sample
0.71
histone modification site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.45   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.45   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
NRGN
Tbio
Novelty:  0.00352757
p_int:  0.999999968
p_ni:  1.9e-8
p_wrong:  1.3e-8
Score:  0.369
Data Source:  BioPlex,STRINGDB
YJU2
Tdark
Novelty:  0.75647391
p_int:  0.99999989
p_ni:  1.09e-7
p_wrong:  2e-9
Score:  0.207
Data Source:  BioPlex,STRINGDB
SNAP29
Tbio
Novelty:  0.02009206
p_int:  0.999994885
p_ni:  0.000005111
p_wrong:  4e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
NUP88
Tbio
Novelty:  0.02483503
p_int:  0.999930949
p_ni:  0.000068894
p_wrong:  1.58e-7
Score:  0.209
Data Source:  BioPlex,STRINGDB
SFN
Tbio
Novelty:  0.00340233
p_int:  0.999718457
p_ni:  0.000252478
p_wrong:  0.000029065
Score:  0.276
Data Source:  BioPlex,STRINGDB
PML
Tbio
Novelty:  0.00285474
Score:  0.938
Data Source:  STRINGDB
IRF3
Tbio
Family:  TF
Novelty:  0.00099474
Score:  0.915
Data Source:  STRINGDB
IRF1
Tbio
Family:  TF
Novelty:  0.00099983
Score:  0.911
Data Source:  STRINGDB
IRF8
Tbio
Family:  TF
Novelty:  0.00330143
Score:  0.909
Data Source:  STRINGDB
OASL
Tbio
Family:  Enzyme
Novelty:  0.01502223
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 62
709927
Mouse
MGI:1914775
67525
Rat
RGD:1586169
313045
Dog
tripartite motif containing 62
VGNC:47830
487300
Cow
tripartite motif containing 62
VGNC:36345
516886
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 62
Mouse
Rat
Dog
tripartite motif containing 62
Cow
tripartite motif containing 62
Publication Statistics
PubMed Score 14.45
PubMed score by year
PubTator Score 9.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title