Tdark TRIM60 Tripartite motif-containing protein 60

Protein Summary

Description

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• Q495X7
• Q8NA35

Gene Name

• TRIM60

Ensembl ID

• ENST00000341062
• ENSP00000343765
• ENSG00000176979
• ENST00000508504
• ENSP00000426496
• ENST00000512596
• ENSP00000421142
• ENST00000647760
• ENSP00000497401

Symbol

• RNF129
• RNF33
• RNF33
• RNF129

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
cell type or tissue	0.72
cell line	0.58
tissue	0.57
chemical	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.01   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 45   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.01   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 45   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0