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Tbio
TRIM59
Tripartite motif-containing protein 59

Protein Summary
Description
May serve as a multifunctional regulator for innate immune signaling pathways.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309784
  • ENSP00000311219
  • ENSG00000213186

Symbol
  • RNF104
  • TRIM57
  • TSBF1
  • MRF1
  • TSBF1
  • IFT80L
  • RNF104
  • TRIM57
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
virus perturbation
0.85
gene perturbation
0.83
histone modification site profile
0.79
tissue
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.96   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.96   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999997244
p_ni:  0.000002715
p_wrong:  4.2e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
ABHD5
Tbio
Family:  Enzyme
Novelty:  0.00806614
p_int:  0.999397112
p_ni:  0.00000608
p_wrong:  0.000596807
Score:  0.333
Data Source:  BioPlex,STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.816338638
p_ni:  0.000059693
p_wrong:  0.183601669
Data Source:  BioPlex
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
Score:  0.933
Data Source:  STRINGDB
ECSIT
Tbio
Novelty:  0.04690184
Score:  0.802
Data Source:  STRINGDB
IFT80
Tbio
Novelty:  0.04862973
Score:  0.789
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.709
Data Source:  STRINGDB
NSRP1
Tbio
Novelty:  0.22397628
Score:  0.651
Data Source:  STRINGDB
TRAT1
Tbio
Novelty:  0.0015709
Score:  0.642
Data Source:  STRINGDB
ELOVL2
Tbio
Novelty:  0.00665823
Score:  0.582
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
2
2
90.4
total cholesterol measurement
3
3
3
85.3
Oral ulcer
1
1
0
1.2
77.3
glutamine measurement
1
1
1
66.7
alanine measurement
1
1
1
63.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
90.4
total cholesterol measurement
3
85.3
Oral ulcer
0
1.2
77.3
glutamine measurement
1
66.7
alanine measurement
1
63.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 59
704829
Mouse
MGI:1914199
66949
Rat
RGD:1311956
365813
Dog
tripartite motif containing 59
VGNC:47829
488133
Horse
tripartite motif containing 59
VGNC:24518
100049895
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 59
Mouse
Rat
Dog
tripartite motif containing 59
Horse
tripartite motif containing 59
Publication Statistics
PubMed Score 54.96
PubMed score by year
PubTator Score 13.13
PubTator score by year
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Related Publications
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PMID
Year
Title