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Tbio
TRIM39
E3 ubiquitin-protein ligase TRIM39

Protein Summary
Description
E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376656
  • ENSP00000365844
  • ENSG00000204599
  • ENST00000376659
  • ENSP00000365847
  • ENST00000383601
  • ENSP00000373095
  • ENSG00000206495
  • ENST00000383602
  • ENSP00000373096
  • ENST00000383603
  • ENSP00000373097
  • ENST00000396547
  • ENSP00000379796
  • ENST00000396548
  • ENSP00000379797
  • ENST00000396551
  • ENSP00000379800
  • ENST00000400644
  • ENSP00000383486
  • ENST00000413715
  • ENSP00000411949
  • ENSG00000224994
  • ENST00000414015
  • ENSP00000401071
  • ENST00000419790
  • ENSP00000401184
  • ENSG00000229929
  • ENST00000424575
  • ENSP00000409902
  • ENSG00000230308
  • ENST00000426469
  • ENSP00000397043
  • ENST00000430502
  • ENSP00000398956
  • ENSG00000232839
  • ENST00000431272
  • ENSP00000396986
  • ENST00000433900
  • ENSP00000389852
  • ENST00000438076
  • ENSP00000389198
  • ENST00000438859
  • ENSP00000411582
  • ENSG00000226437
  • ENST00000440117
  • ENSP00000392130
  • ENST00000443109
  • ENSP00000414525
  • ENST00000445206
  • ENSP00000391917
  • ENST00000446397
  • ENSP00000412743
  • ENST00000449318
  • ENSP00000404904
  • ENST00000450778
  • ENSP00000387445
  • ENST00000451132
  • ENSP00000394353
  • ENST00000451715
  • ENSP00000398355
  • ENST00000452705
  • ENSP00000415259
  • ENST00000458607
  • ENSP00000404340
  • ENST00000547030
  • ENSP00000449847
  • ENST00000548002
  • ENSP00000447835
  • ENST00000549841
  • ENSP00000448572
  • ENST00000550282
  • ENSP00000449272
  • ENST00000552337
  • ENSP00000450288
  • ENST00000552520
  • ENSP00000448462

Symbol
  • RNF23
  • TFP
  • TFP
  • RNF23
  • TRIM39B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
interacting protein
0.67
protein complex
0.66
tissue sample
0.64
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.13   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.13   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (299)
ZNF764
Tdark
Family:  TF
Novelty:  0.76308829
p_int:  0.999995477
p_ni:  0.000004523
Score:  0.154
Data Source:  BioPlex,STRINGDB
ZNF354C
Tdark
Family:  TF
Novelty:  0.09978239
p_int:  0.999991708
p_ni:  0.000008292
Score:  0.173
Data Source:  BioPlex,STRINGDB
ZNF621
Tdark
Family:  TF
Novelty:  1.96460285
p_int:  0.999990977
p_ni:  0.000009023
Score:  0.251
Data Source:  BioPlex,STRINGDB
ZNF223
Tdark
Family:  TF
Novelty:  0.78390275
p_int:  0.999978722
p_ni:  0.000021278
Score:  0.168
Data Source:  BioPlex,STRINGDB
ZNF707
Tdark
Family:  TF
Novelty:  1.42194815
p_int:  0.999965203
p_ni:  0.000034797
Score:  0.155
Data Source:  BioPlex,STRINGDB
ZNF311
Tdark
Family:  TF
Novelty:  0.4280137
p_int:  0.999951169
p_ni:  0.000048831
Score:  0.219
Data Source:  BioPlex,STRINGDB
ZNF19
Tdark
Family:  TF
Novelty:  0.95106537
p_int:  0.999942114
p_ni:  0.000057886
Score:  0.537
Data Source:  BioPlex,STRINGDB
ZIM2
Tbio
Family:  TF
Novelty:  0.08135678
p_int:  0.999796593
p_ni:  0.000203407
Score:  0.207
Data Source:  BioPlex,STRINGDB
ZNF331
Tbio
Family:  TF
Novelty:  0.05976217
p_int:  0.999789188
p_ni:  0.000210812
Score:  0.158
Data Source:  BioPlex,STRINGDB
ZNF726
Tdark
Family:  TF
Novelty:  5.86666667
p_int:  0.999781514
p_ni:  0.000218486
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (189)
Items per page:
1 – 5 of 189
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
6
4
8
96.4
reticulocyte count
6
4
8
96.4
reticulocyte count
6
4
8
96.4
reticulocyte count
6
4
8
96.4
reticulocyte count
6
4
8
96.4
Items per page:
1 – 5 of 189
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
8
96.4
reticulocyte count
8
96.4
reticulocyte count
8
96.4
reticulocyte count
8
96.4
reticulocyte count
8
96.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 39
VGNC:53445
462537
Mouse
MGI:1890659
79263
Rat
RGD:1303115
309591
Pig
tripartite motif containing 39
100151742
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 39
Mouse
Rat
Pig
tripartite motif containing 39
Publication Statistics
PubMed Score 12.13
PubMed score by year
PubTator Score 7.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title