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Tbio
TRIM37
E3 ubiquitin-protein ligase TRIM37

Protein Summary
Description
E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:25470042). Has anti-HIV activity (PubMed:24317724). This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262294
  • ENSP00000262294
  • ENSG00000108395
  • ENST00000393065
  • ENSP00000376784
  • ENST00000393066
  • ENSP00000376785

Symbol
  • KIAA0898
  • MUL
  • POB1
  • MUL
  • POB1
  • TEF3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
histone modification site profile
0.91
molecular function
0.88
disease perturbation
0.87
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.39   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.39   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (326)
ZNF816
Tdark
Family:  TF
Novelty:  0.59861195
p_int:  0.999994719
p_ni:  0.000005267
p_wrong:  1.4e-8
Score:  0.208
Data Source:  BioPlex,STRINGDB
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.99998799
p_ni:  0.000012006
p_wrong:  5e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
ZNF610
Tdark
Family:  TF
Novelty:  1.33582282
p_int:  0.999986652
p_ni:  0.000013348
Score:  0.229
Data Source:  BioPlex,STRINGDB
ZNF550
Tdark
Family:  TF
Novelty:  18
p_int:  0.998923964
p_ni:  0.001059484
p_wrong:  0.000016552
Score:  0.169
Data Source:  BioPlex,STRINGDB
ZNF554
Tdark
Family:  TF
Novelty:  1.57478216
p_int:  0.998894369
p_ni:  0.000812141
p_wrong:  0.000293489
Data Source:  BioPlex
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.995388607
p_ni:  0.004609478
p_wrong:  0.000001916
Data Source:  BioPlex
ZNF74
Tbio
Family:  TF
Novelty:  0.10554307
p_int:  0.993552187
p_ni:  0.00641349
p_wrong:  0.000034324
Data Source:  BioPlex
PI15
Tbio
Family:  Enzyme
Novelty:  0.02244161
p_int:  0.991216303
p_ni:  0.008035367
p_wrong:  0.00074833
Data Source:  BioPlex
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.98456814
p_ni:  0.015425784
p_wrong:  0.000006077
Data Source:  BioPlex
ZNF263
Tbio
Family:  TF
Novelty:  0.098799
p_int:  0.980570624
p_ni:  0.019420757
p_wrong:  0.000008619
Score:  0.156
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
3
1
7.5
77.8
mean corpuscular volume
1
1
1
71.6
mean reticulocyte volume
1
1
1
68.3
self reported educational attainment
1
1
1
35
cognitive function measurement
2
1
2
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
7.5
77.8
mean corpuscular volume
1
71.6
mean reticulocyte volume
1
68.3
self reported educational attainment
1
35
cognitive function measurement
2
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 37
710934
Mouse
MGI:2153072
68729
Rat
RGD:1308349
360592
Dog
tripartite motif containing 37
VGNC:47818
480575
Horse
tripartite motif containing 37
VGNC:24506
100057121
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 37
Mouse
Rat
Dog
tripartite motif containing 37
Horse
tripartite motif containing 37
Publication Statistics
PubMed Score 58.39
PubMed score by year
PubTator Score 52.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title