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Tbio
TRIM35
Tripartite motif-containing protein 35

Protein Summary
Description
Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (PubMed:25263439). Involved in the cell death mechanism (By similarity). The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305364
  • ENSP00000301924
  • ENSG00000104228

Symbol
  • HLS5
  • KIAA1098
  • HLS5
  • MAIR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor binding site profile
0.7
histone modification site profile
0.62
tissue sample
0.62
transcription factor perturbation
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.79   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.79   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (170)
TRIM10
Tbio
Novelty:  0.27685659
p_int:  0.999998597
p_ni:  0.000001402
p_wrong:  1e-9
Score:  0.361
Data Source:  BioPlex,STRINGDB
CHMP2A
Tbio
Novelty:  0.00169253
p_int:  0.99999577
p_ni:  0.000004174
p_wrong:  5.6e-8
Score:  0.201
Data Source:  BioPlex,STRINGDB
AKTIP
Tbio
Novelty:  0.00315951
p_int:  0.99991414
p_ni:  0.000072854
p_wrong:  0.000013006
Score:  0.203
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.999905609
p_ni:  0.000094391
Data Source:  BioPlex
OTUD5
Tbio
Novelty:  0.0498487
p_int:  0.999901788
p_ni:  0.000020986
p_wrong:  0.000077227
Score:  0.204
Data Source:  BioPlex,STRINGDB
KDM5C
Tchem
Family:  TF; Epigenetic
Novelty:  0.00701855
p_int:  0.997974795
p_ni:  0.002025118
p_wrong:  8.7e-8
Score:  0.272
Data Source:  BioPlex,STRINGDB
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.987534916
p_ni:  0.007677625
p_wrong:  0.004787458
Score:  0.183
Data Source:  BioPlex,STRINGDB
WDR20
Tbio
Novelty:  0.03031804
p_int:  0.983884516
p_ni:  0.016115484
Score:  0.159
Data Source:  BioPlex,STRINGDB
LIMD1
Tbio
Novelty:  0.04868333
p_int:  0.976353739
p_ni:  0.02175283
p_wrong:  0.00189343
Score:  0.151
Data Source:  BioPlex,STRINGDB
PPP2R1B
Tbio
Family:  Enzyme
Novelty:  0.03936638
p_int:  0.954222065
p_ni:  0.045777935
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
67.1
4
1
0
1.1
65.6
family history of Alzheimer’s disease
2
1
0
3.9
65.6
myeloid white cell count
1
1
1
62.1
eosinophil count
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
67.1
0
1.1
65.6
family history of Alzheimer’s disease
0
3.9
65.6
myeloid white cell count
1
62.1
eosinophil count
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 35
VGNC:773
464072
Macaque
tripartite motif containing 35
712720
Mouse
MGI:1914104
66854
Rat
RGD:1564642
498538
Dog
tripartite motif containing 35
VGNC:47816
486103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 35
Macaque
tripartite motif containing 35
Mouse
Rat
Dog
tripartite motif containing 35
Publication Statistics
PubMed Score 30.79
PubMed score by year
PubTator Score 21.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title