You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TRIM34
Tripartite motif-containing protein 34

Protein Summary
Description
May function as antiviral protein and may contribute to the defense against retroviral infections. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000429814
  • ENSP00000402595
  • ENSG00000258659
  • ENST00000514226
  • ENSP00000422947

Symbol
  • IFP1
  • RNF21
  • IFP1
  • RNF21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
microRNA
0.82
cell type or tissue
0.81
tissue sample
0.7
virus perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.92   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.92   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (13)
TRAT1
Tbio
Novelty:  0.0015709
Score:  0.719
Data Source:  STRINGDB
FLG2
Tbio
Novelty:  0.03211244
Score:  0.671
Data Source:  STRINGDB
BBOX1
Tchem
Family:  Enzyme
Novelty:  0.00255489
Score:  0.587
Data Source:  STRINGDB
UBE2K
Tbio
Novelty:  0.00214955
Score:  0.531
Data Source:  STRINGDB
PML
Tbio
Novelty:  0.00285474
Score:  0.49
Data Source:  STRINGDB
TMLHE
Tbio
Family:  Enzyme
Novelty:  0.02023468
Score:  0.481
Data Source:  STRINGDB
BTBD1
Tbio
Novelty:  0.19772296
Score:  0.47
Data Source:  STRINGDB
BTBD2
Tbio
Novelty:  0.23314987
Score:  0.47
Data Source:  STRINGDB
SAMHD1
Tbio
Family:  Enzyme
Novelty:  0.00294595
Score:  0.461
Data Source:  STRINGDB
CRYM
Tbio
Family:  Enzyme
Novelty:  0.02044871
Score:  0.451
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
5
8
98.3
alkaline phosphatase measurement
3
2
2
16.7
94.5
apolipoprotein B measurement
2
3
3
88.7
low density lipoprotein cholesterol measurement
4
2
5
84.6
glomerular filtration rate
3
3
3
83.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
8
98.3
alkaline phosphatase measurement
2
16.7
94.5
apolipoprotein B measurement
3
88.7
low density lipoprotein cholesterol measurement
5
84.6
glomerular filtration rate
3
83.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 29.92
PubMed score by year
PubTator Score 10.23
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title