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Tbio
TRIM32
E3 ubiquitin-protein ligase TRIM32

Protein Summary
Description
Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373983
  • ENSP00000363095
  • ENSG00000119401
  • ENST00000450136
  • ENSP00000408292

Symbol
  • HT2A
  • HT2A
  • BBS11
  • TATIP
  • LGMD2H
  • LGMDR8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
biological process
0.95
molecular function
0.94
kinase perturbation
0.93
tissue sample
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 982.99   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 982.99   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (382)
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.999989577
p_ni:  0.000010423
Score:  0.709
Data Source:  BioPlex,STRINGDB
SEC23IP
Tbio
Novelty:  0.0925721
p_int:  0.999932281
p_ni:  0.000067719
Score:  0.199
Data Source:  BioPlex,STRINGDB
SEPT6
Tbio
Novelty:  0.00885503
p_int:  0.999820973
p_ni:  0.000179027
Data Source:  BioPlex
EXOC1
Tbio
Novelty:  0.01073858
p_int:  0.99906661
p_ni:  0.00093339
Data Source:  BioPlex
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.992423143
p_ni:  0.007576857
Score:  0.838
Data Source:  BioPlex,STRINGDB
NGB
Tbio
Novelty:  0.00247805
p_int:  0.988939262
p_ni:  0.011060738
Score:  0.206
Data Source:  BioPlex,STRINGDB
AKTIP
Tbio
Novelty:  0.00315951
p_int:  0.981477356
p_ni:  0.018522644
Score:  0.196
Data Source:  BioPlex,STRINGDB
TULP2
Tdark
Family:  TF
Novelty:  0.20144336
p_int:  0.926778379
p_ni:  0.073221621
Data Source:  BioPlex
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.90688528
p_ni:  0.093114695
p_wrong:  2.5e-8
Data Source:  BioPlex
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.90448107
p_ni:  0.09551893
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Cytosolic sensors of pathogen-associated DNA
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (47)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
54.4
FEV/FEC ratio
1
1
1
46.9
glomerular filtration rate
1
1
1
40.7
BMI-adjusted hip circumference
1
1
1
35
hip geometry
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
54.4
FEV/FEC ratio
1
46.9
glomerular filtration rate
1
40.7
BMI-adjusted hip circumference
1
35
hip geometry
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 32
VGNC:4890
742944
Macaque
tripartite motif containing 32
702595
Mouse
MGI:1917057
69807
Rat
RGD:1305238
313264
Dog
tripartite motif containing 32
VGNC:47814
102152434
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 32
Macaque
tripartite motif containing 32
Mouse
Rat
Dog
tripartite motif containing 32
Publication Statistics
PubMed Score 982.99
PubMed score by year
PubTator Score 44.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title