Tbio TRIM3 Tripartite motif-containing protein 3

Protein Summary

Description

Probably involved in vesicular trafficking via its association with the CART complex (PubMed:15772161). The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75382
• B7Z5E6
• F5H2Q8
• Q4V9L4
• Q9C038
• Q9C039

Gene Name

• TRIM3

Ensembl ID

• ENST00000345851
• ENSP00000340797
• ENSG00000110171
• ENST00000359518
• ENSP00000352508
• ENST00000525074
• ENSP00000433102
• ENST00000536344
• ENSP00000445460

Symbol

• BERP
• RNF22
• RNF97
• BERP
• HAC1
• RNF22
• RNF97

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
kinase perturbation	0.81
hub protein	0.71
small molecule perturbation	0.65
tissue sample	0.64

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / Tripartite Motif-containing Protein 3

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / Tripartite Motif-containing Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.75   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 227   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.75   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0