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Tbio
TRIM29
Tripartite motif-containing protein 29

Protein Summary
Description
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of TMEM173/STING in a similar way, leading to its degradation. The protein encoded by this gene belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, it may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. It may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341846
  • ENSP00000343129
  • ENSG00000137699

Symbol
  • ATDC
  • ATDC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.8
PubMedID
0.76
small molecule perturbation
0.72
transcription factor perturbation
0.68
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.94   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 557   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.94   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 557   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (196)
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.999701727
p_ni:  0.000298273
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.99938655
p_ni:  0.00061345
Data Source:  BioPlex
RBM24
Tbio
Novelty:  0.04562076
p_int:  0.998813376
p_ni:  0.001186623
Data Source:  BioPlex
FBXO3
Tbio
Novelty:  0.01701102
p_int:  0.998142209
p_ni:  0.001857567
p_wrong:  2.23e-7
Data Source:  BioPlex
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.997823366
p_ni:  0.002176634
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.99722236
p_ni:  0.002777564
p_wrong:  7.6e-8
Data Source:  BioPlex
SLC6A1
Tclin
Family:  Transporter
Novelty:  0.00165116
p_int:  0.988909366
p_ni:  0.011090209
p_wrong:  4.24e-7
Data Source:  BioPlex
FBXL4
Tbio
Novelty:  0.04286856
p_int:  0.988629321
p_ni:  0.011370674
p_wrong:  4e-9
Data Source:  BioPlex
CCNYL1
Tdark
Novelty:  0.45350824
p_int:  0.987192989
p_ni:  0.012807002
p_wrong:  9e-9
Data Source:  BioPlex
KIF3A
Tbio
Novelty:  0.00555124
p_int:  0.9828848
p_ni:  0.0171152
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
2
2
81.8
vitamin D measurement
3
1
3
74
urinary albumin to creatinine ratio
3
2
3
66
urate measurement
1
1
1
23.6
mean arterial pressure
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
81.8
vitamin D measurement
3
74
urinary albumin to creatinine ratio
3
66
urate measurement
1
23.6
mean arterial pressure
1
4.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 29
VGNC:961
451615
Macaque
tripartite motif containing 29
705796
Mouse
MGI:1919419
72169
Rat
RGD:1307858
300656
Dog
tripartite motif containing 29
VGNC:47812
489362
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 29
Macaque
tripartite motif containing 29
Mouse
Rat
Dog
tripartite motif containing 29
Publication Statistics
PubMed Score 64.94
PubMed score by year
PubTator Score 41.44
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title