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Tbio
TRIM28
Transcription intermediary factor 1-beta

Protein Summary
Description
Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity towar ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253024
  • ENSP00000253024
  • ENSG00000130726
  • ENST00000341753
  • ENSP00000342232

Symbol
  • KAP1
  • RNF96
  • TIF1B
  • KAP1
  • TF1B
  • RNF96
  • TIF1B
  • PPP1R157
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
hub protein
1
interacting protein
1
co-expressed gene
0.99
protein domain
0.99


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.05   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 661   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 195.05   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 661   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (510)
POGK
Tdark
Novelty:  0.17276635
p_int:  0.999999959
p_ni:  3.9e-8
p_wrong:  2e-9
Data Source:  BioPlex
ZNF30
Tdark
Family:  TF
Novelty:  1.40379259
p_int:  0.999999194
p_ni:  8.06e-7
Score:  0.935
Data Source:  BioPlex,STRINGDB
ZNF28
Tdark
Family:  TF
Novelty:  0.60861294
p_int:  0.999998704
p_ni:  0.000001209
p_wrong:  8.7e-8
Score:  0.92
Data Source:  BioPlex,STRINGDB
ZNF573
Tdark
Family:  TF
Novelty:  2.6663167
p_int:  0.99999825
p_wrong:  0.000001749
Score:  0.934
Data Source:  BioPlex,STRINGDB
ZNF250
Tdark
Family:  TF
Novelty:  2.37207478
p_int:  0.999998171
p_ni:  0.000001829
Score:  0.944
Data Source:  BioPlex,STRINGDB
ZNF274
Tbio
Family:  TF
Novelty:  0.01432522
p_int:  0.999997858
p_ni:  0.000002142
Score:  0.981
Data Source:  BioPlex,STRINGDB
ZNF112
Tdark
Family:  TF
Novelty:  0.9242381
p_int:  0.999994182
p_wrong:  0.000005817
Score:  0.942
Data Source:  BioPlex,STRINGDB
ZNF620
Tdark
Family:  TF
Novelty:  2.57179565
p_int:  0.999990924
p_ni:  0.000009074
p_wrong:  3e-9
Score:  0.917
Data Source:  BioPlex,STRINGDB
ZNF268
Tbio
Family:  TF
Novelty:  0.0471762
p_int:  0.99998964
p_ni:  0.000010345
p_wrong:  1.5e-8
Score:  0.937
Data Source:  BioPlex,STRINGDB
ZNF721
Tdark
Family:  TF
Novelty:  0.47000061
p_int:  0.999988077
p_ni:  1.02e-7
p_wrong:  0.000011821
Score:  0.933
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (29)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Post-translational protein modification
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (46)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
69.2
mathematical ability
3
2
3
67.2
intelligence
1
1
0
6.2
51.3
mean reticulocyte volume
1
1
1
38.8
red blood cell distribution width
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
69.2
mathematical ability
3
67.2
intelligence
0
6.2
51.3
mean reticulocyte volume
1
38.8
red blood cell distribution width
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 28
711982
Mouse
MGI:109274
21849
Rat
RGD:620289
116698
Dog
tripartite motif containing 28
VGNC:47811
403689
Horse
tripartite motif containing 28
VGNC:24499
100064831
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 28
Mouse
Rat
Dog
tripartite motif containing 28
Horse
tripartite motif containing 28
Publication Statistics
PubMed Score 195.05
PubMed score by year
PubTator Score 184.38
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title