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Tbio
TRIM25
E3 ubiquitin/ISG15 ligase TRIM25

Protein Summary
Description
Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784). The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this prot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316881
  • ENSP00000323889
  • ENSG00000121060
  • ENST00000537230
  • ENSP00000445961

Symbol
  • EFP
  • RNF147
  • ZNF147
  • EFP
  • Z147
  • RNF147
  • ZNF147
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.97
transcription factor binding site profile
0.96
small molecule perturbation
0.93
PubMedID
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.36   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 473   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 229.36   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 473   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (307)
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.99956361
p_ni:  0.000436388
p_wrong:  3e-9
Data Source:  BioPlex
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.996575946
p_ni:  0.003421203
p_wrong:  0.000002851
Score:  0.173
Data Source:  BioPlex,STRINGDB
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.996422897
p_ni:  0.001736906
p_wrong:  0.001840197
Score:  0.214
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.996234295
p_ni:  0.003693245
p_wrong:  0.000072461
Data Source:  BioPlex
G3BP2
Tbio
Family:  Enzyme
Novelty:  0.04786241
p_int:  0.926957766
p_ni:  0.07299499
p_wrong:  0.000047244
Score:  0.475
Data Source:  BioPlex,STRINGDB
DDX58
Tbio
Family:  Enzyme
Novelty:  0.00080099
Score:  0.995
Data Source:  Reactome,STRINGDB
MAVS
Tbio
Novelty:  0.00241215
Score:  0.993
Data Source:  Reactome,STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.991
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.988
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.982
Data Source:  STRINGDB
Pathways (117)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

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1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
DDX58/IFIH1-mediated induction of interferon-alpha/beta
DNA Damage Bypass
DNA Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Mutant Phenotype (IMP)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
2
3
76.4
1
1
0
1.1
44.2
1
1
0
1.1
36.9
BMI-adjusted hip circumference
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
76.4
0
1.1
44.2
0
1.1
36.9
BMI-adjusted hip circumference
1
8.3
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IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 25
VGNC:9739
455146
Macaque
tripartite motif containing 25
712588
Mouse
MGI:102749
217069
Rat
RGD:1594396
494338
Dog
tripartite motif containing 25
VGNC:47810
491103
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 25
Macaque
tripartite motif containing 25
Mouse
Rat
Dog
tripartite motif containing 25
Publication Statistics
PubMed Score 229.36
PubMed score by year
PubTator Score 73.11
PubTator score by year
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Related Publications
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PMID
Year
Title