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Tbio
TRIM22
E3 ubiquitin-protein ligase TRIM22

Protein Summary
Description
Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379965
  • ENSP00000369299
  • ENSG00000132274

Symbol
  • RNF94
  • STAF50
  • RNF94
  • STAF50
  • GPSTAF50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
protein domain
0.97
biological process
0.81
microRNA
0.73
gene perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.23   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.23   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
GBP1
Tbio
Novelty:  0.00634662
Score:  0.978
Data Source:  STRINGDB
OAS2
Tbio
Family:  Enzyme
Novelty:  0.01673393
Score:  0.975
Data Source:  STRINGDB
PML
Tbio
Novelty:  0.00285474
Score:  0.971
Data Source:  STRINGDB
IRF9
Tbio
Family:  TF
Novelty:  0.00751233
Score:  0.958
Data Source:  STRINGDB
OAS1
Tbio
Family:  Enzyme
Novelty:  0.00532331
Score:  0.954
Data Source:  STRINGDB
IRF7
Tbio
Family:  TF
Novelty:  0.0021839
Score:  0.953
Data Source:  STRINGDB
OAS3
Tbio
Family:  Enzyme
Novelty:  0.02422229
Score:  0.951
Data Source:  STRINGDB
OASL
Tbio
Family:  Enzyme
Novelty:  0.01502223
Score:  0.95
Data Source:  STRINGDB
GBP5
Tbio
Novelty:  0.03705719
Score:  0.95
Data Source:  STRINGDB
IRF1
Tbio
Family:  TF
Novelty:  0.00099983
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
3
2
2
16.7
92.8
mean platelet volume
3
5
8
90.3
low density lipoprotein cholesterol measurement
5
2
6
89.4
apolipoprotein B measurement
3
3
4
88.3
platelet count
5
4
6
80.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
16.7
92.8
mean platelet volume
8
90.3
low density lipoprotein cholesterol measurement
6
89.4
apolipoprotein B measurement
4
88.3
platelet count
6
80.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 22
VGNC:962
450985
Macaque
tripartite motif containing 22
713814
Dog
tripartite motif containing 22
VGNC:52856
485284
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 22
Macaque
tripartite motif containing 22
Dog
tripartite motif containing 22
Publication Statistics
PubMed Score 72.23
PubMed score by year
PubTator Score 43.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title