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Tbio
TRIM16
Tripartite motif-containing protein 16

Protein Summary
Description
E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. Thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336708
  • ENSP00000338989
  • ENSG00000221926
  • ENST00000577886
  • ENSP00000462903
  • ENST00000578237
  • ENSP00000463188
  • ENST00000649191
  • ENSP00000497185

Symbol
  • EBBP
  • EBBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
protein domain
0.85
small molecule perturbation
0.76
transcription factor perturbation
0.74
cell type or tissue
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.79   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.79   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
TRIM16L
Tdark
Novelty:  1.32785612
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.564
Data Source:  BioPlex,STRINGDB
OPTN
Tbio
Novelty:  0.00080427
p_int:  0.7718292
p_ni:  0.000034128
p_wrong:  0.228136672
Score:  0.403
Data Source:  BioPlex,STRINGDB
TRAT1
Tbio
Novelty:  0.0015709
Score:  0.673
Data Source:  STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
Score:  0.643
Data Source:  STRINGDB
BBOX1
Tchem
Family:  Enzyme
Novelty:  0.00255489
Score:  0.641
Data Source:  STRINGDB
FGF7
Tbio
Novelty:  0.00083346
Score:  0.635
Data Source:  STRINGDB
LAMTOR1
Tbio
Novelty:  0.04952213
Score:  0.577
Data Source:  STRINGDB
FGF10
Tbio
Novelty:  0.00217451
Score:  0.574
Data Source:  STRINGDB
IL17RA
Tclin
Novelty:  0.00416706
Score:  0.549
Data Source:  STRINGDB
LMOD1
Tbio
Novelty:  0.04769107
Score:  0.547
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif-containing protein 16-like
107972389
Mouse
MGI:2137356
94092
Rat
RGD:1309749
303214
Anole lizard
tripartite motif containing 16
100554999
Zebrafish
ZDB-GENE-090512-6
568734
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif-containing protein 16-like
Mouse
Rat
Anole lizard
tripartite motif containing 16
Zebrafish
Publication Statistics
PubMed Score 40.79
PubMed score by year
PubTator Score 17.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title