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Tbio
TRIM13
E3 ubiquitin-protein ligase TRIM13

Protein Summary
Description
Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor (PubMed:22178386). Plays also a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809). Participates as well in T-cell receptor-mediated NF-kappa-B activation (PubMed:25088585). In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEM ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356017
  • ENSP00000348299
  • ENSG00000204977
  • ENST00000378182
  • ENSP00000367424
  • ENST00000420995
  • ENSP00000412943
  • ENST00000457662
  • ENSP00000399206

Symbol
  • LEU5
  • RFP2
  • RNF77
  • CAR
  • LEU5
  • RFP2
  • DLEU5
  • RNF77
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.83
disease perturbation
0.79
transcription factor binding site profile
0.69
virus perturbation
0.68
histone modification site profile
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1215.55   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1215.55   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
COMMD10
Tbio
Novelty:  0.29057641
p_int:  0.999998209
p_ni:  0.000001791
Score:  0.183
Data Source:  BioPlex,STRINGDB
TMEM130
Tdark
Novelty:  1.39618601
p_int:  0.999993403
p_ni:  0.000006462
p_wrong:  1.34e-7
Data Source:  BioPlex
ELOVL2
Tbio
Novelty:  0.00665823
p_int:  0.999958507
p_ni:  0.000041397
p_wrong:  9.6e-8
Score:  0.187
Data Source:  BioPlex,STRINGDB
ABCG2
Tchem
Family:  Transporter
Novelty:  0.00029779
p_int:  0.999953152
p_ni:  0.000046638
p_wrong:  2.1e-7
Data Source:  BioPlex
TEX28
Tdark
Novelty:  0.10581423
p_int:  0.999937617
p_ni:  0.000062381
p_wrong:  3e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
LRRN2
Tdark
Novelty:  0.22583761
p_int:  0.999660006
p_ni:  0.000202868
p_wrong:  0.000137126
Score:  0.167
Data Source:  BioPlex,STRINGDB
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.99961909
p_ni:  0.000022823
p_wrong:  0.000358088
Data Source:  BioPlex
KIR3DL2
Tbio
Novelty:  0.00321353
p_int:  0.88862363
p_ni:  0.000381535
p_wrong:  0.110994835
Score:  0.175
Data Source:  BioPlex,STRINGDB
NPLOC4
Tbio
Novelty:  0.01690434
p_int:  0.781709284
p_ni:  0.218290716
Score:  0.234
Data Source:  BioPlex,STRINGDB
CKAP4
Tbio
Novelty:  0.02104039
p_int:  0.770181856
p_ni:  0.229818144
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
ER Quality Control Compartment (ERQC)
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
ER Quality Control Compartment (ERQC)
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
3
3
92.3
sex hormone-binding globulin measurement
4
3
6
91.1
body height
2
1
2
73.5
BMI-adjusted hip circumference
1
3
3
66.2
heel bone mineral density
2
2
2
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
92.3
sex hormone-binding globulin measurement
6
91.1
body height
2
73.5
BMI-adjusted hip circumference
3
66.2
heel bone mineral density
2
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 13
707239
Mouse
MGI:1913847
66597
Rat
RGD:1307609
364398
Dog
tripartite motif containing 13
VGNC:47805
607845
Horse
tripartite motif containing 13
VGNC:24493
100055194
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tripartite motif containing 13
Mouse
Rat
Dog
tripartite motif containing 13
Horse
tripartite motif containing 13
Publication Statistics
PubMed Score 1215.55
PubMed score by year
PubTator Score 220.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title