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Tbio
TRIM10
Tripartite motif-containing protein 10

Protein Summary
Description
Seems to play an important role in erythropoiesis. The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic bodies. Studies in mice suggest that this protein plays a role in terminal differentiation of erythroid cells. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259941
  • ENSP00000259941
  • ENSG00000137394
  • ENST00000354038
  • ENSP00000343695
  • ENST00000376704
  • ENSP00000365894
  • ENSG00000204613
  • ENST00000413055
  • ENSP00000393787
  • ENSG00000227472
  • ENST00000416714
  • ENSP00000405578
  • ENSG00000229381
  • ENST00000417411
  • ENSP00000393576
  • ENSG00000237192
  • ENST00000426996
  • ENSP00000397440
  • ENST00000428611
  • ENSP00000412370
  • ENSG00000229346
  • ENST00000431258
  • ENSP00000395598
  • ENSG00000235025
  • ENST00000446013
  • ENSP00000398404
  • ENSG00000237703
  • ENST00000447465
  • ENSP00000393976
  • ENST00000448645
  • ENSP00000399446
  • ENST00000449208
  • ENSP00000390497
  • ENST00000449742
  • ENSP00000397073
  • ENST00000451727
  • ENSP00000391445
  • ENST00000456988
  • ENSP00000410849

Symbol
  • RFB30
  • RNF9
  • RNF9
  • HERF1
  • RFB30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
microRNA
0.61
cell type or tissue
0.57
phenotype
0.57
disease perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.49   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.49   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (168)
FAM193B
Tdark
Novelty:  1.69956634
p_int:  0.999999995
p_ni:  3e-9
p_wrong:  1e-9
Score:  0.39
Data Source:  BioPlex,STRINGDB
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.999999943
p_ni:  4.4e-8
p_wrong:  1.3e-8
Score:  0.261
Data Source:  BioPlex,STRINGDB
TRIM35
Tbio
Novelty:  0.03280419
p_int:  0.999998597
p_ni:  0.000001402
p_wrong:  1e-9
Score:  0.361
Data Source:  BioPlex,STRINGDB
KLHL41
Tbio
Novelty:  0.03973182
p_int:  0.999660903
p_ni:  2.9e-7
p_wrong:  0.000338807
Score:  0.209
Data Source:  BioPlex,STRINGDB
ZMYM2
Tbio
Novelty:  0.0258698
p_int:  0.99753897
p_ni:  0.00246103
Score:  0.424
Data Source:  BioPlex,STRINGDB
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
p_int:  0.995448031
p_ni:  0.004551969
Score:  0.205
Data Source:  BioPlex,STRINGDB
MTMR1
Tbio
Family:  Enzyme
Novelty:  0.06694505
p_int:  0.992410516
p_ni:  0.007589484
Score:  0.183
Data Source:  BioPlex,STRINGDB
EMILIN3
Tbio
Novelty:  0.4
p_int:  0.982943148
p_ni:  0.017056852
Score:  0.188
Data Source:  BioPlex,STRINGDB
TRMT61B
Tbio
Family:  Enzyme
Novelty:  0.32929047
p_int:  0.954663374
p_ni:  0.045336626
Data Source:  BioPlex
POLRMT
Tbio
Family:  Enzyme
Novelty:  0.01398067
p_int:  0.950765914
p_ni:  0.049234086
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon gamma signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon gamma signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (264)
Items per page:
1 – 5 of 264
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
9
13
99.1
reticulocyte measurement
3
9
13
99.1
reticulocyte measurement
3
9
13
99.1
reticulocyte measurement
3
9
13
99.1
reticulocyte measurement
3
9
13
99.1
Items per page:
1 – 5 of 264
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
13
99.1
reticulocyte measurement
13
99.1
reticulocyte measurement
13
99.1
reticulocyte measurement
13
99.1
reticulocyte measurement
13
99.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 10
VGNC:12727
742346
Macaque
tripartite motif containing 10
710173
Mouse
MGI:1338757
19824
Rat
RGD:1359438
294210
Dog
tripartite motif containing 10
VGNC:49639
488345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tripartite motif containing 10
Macaque
tripartite motif containing 10
Mouse
Rat
Dog
tripartite motif containing 10
Publication Statistics
PubMed Score 5.49
PubMed score by year
PubTator Score 1.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title