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Tbio
TREM1
Triggering receptor expressed on myeloid cells 1

Protein Summary
Description
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244709
  • ENSP00000244709
  • ENSG00000124731
  • ENST00000334475
  • ENSP00000334284
  • ENST00000591620
  • ENSP00000465345

Symbol
  • CD354
  • TREM-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
biological term
0.79
biological process
0.71
cell type or tissue
0.71
microRNA
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.99   (req: < 5)
Gene RIFs: 152   (req: <= 3)
Antibodies: 648   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 507.99   (req: >= 5)
Gene RIFs: 152   (req: > 3)
Antibodies: 648   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.989
Data Source:  Reactome,STRINGDB
TREM2
Tbio
Novelty:  0.00228007
Score:  0.918
Data Source:  STRINGDB
TREML2
Tbio
Novelty:  0.05038302
Score:  0.901
Data Source:  STRINGDB
TREML1
Tbio
Novelty:  0.03513416
Score:  0.805
Data Source:  STRINGDB
TLR4
Tchem
Novelty:  0.00010863
Score:  0.783
Data Source:  STRINGDB
FPR1
Tchem
Family:  GPCR
Novelty:  0.00256884
Score:  0.783
Data Source:  STRINGDB
TLR2
Tchem
Novelty:  0.00023242
Score:  0.721
Data Source:  STRINGDB
CLEC5A
Tbio
Novelty:  0.01710591
Score:  0.696
Data Source:  STRINGDB
IL1B
Tclin
Novelty:  0.0000308
Score:  0.679
Data Source:  STRINGDB
TLR8
Tchem
Novelty:  0.0023384
Score:  0.676
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (211)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cell surface interactions at the vascular wall
Reactome
DAP12 interactions
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cell surface interactions at the vascular wall
DAP12 interactions
Hemostasis
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
87.7
leukocyte count
1
1
1
64.4
reticulocyte count
1
1
1
46.1
1
1
1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
87.7
leukocyte count
1
64.4
reticulocyte count
1
46.1
1
0.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
triggering receptor expressed on myeloid cells 1
693558
Mouse
MGI:1930005
58217
Rat
RGD:1309467
301229
Dog
triggering receptor expressed on myeloid cells 1
VGNC:47793
608994
Horse
triggering receptor expressed on myeloid cells 1
VGNC:24481
100054285
Species
Name
OMA
EggNOG
Inparanoid
Macaque
triggering receptor expressed on myeloid cells 1
Mouse
Rat
Dog
triggering receptor expressed on myeloid cells 1
Horse
triggering receptor expressed on myeloid cells 1
Publication Statistics
PubMed Score 507.99
PubMed score by year
PubTator Score 244.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title