Tbio TRDMT1 tRNA (cytosine(38)-C(5))-methyltransferase

Protein Summary

Description

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp). This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• O14717
• B0YJ02
• B0YJ03
• B0YJ07
• B0YJ08
• O43669
• Q86WW6

Gene Name

• TRDMT1

Ensembl ID

• ENST00000377799
• ENSP00000367030
• ENSG00000107614
• ENST00000495022
• ENSP00000417594

Symbol

• DNMT2
• DMNT2
• DNMT2
• PUMET
• RNMT1
• MHSAIIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.77
transcription factor binding site profile	0.72
small molecule perturbation	0.67
virus perturbation	0.64
transcription factor	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.58   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 414   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.58   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0