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Tbio
TRARG1
Trafficking regulator of GLUT4 1

Protein Summary
Description
Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333813
  • ENSP00000329548
  • ENSG00000184811

Symbol
  • IFITMD3
  • LOST1
  • TUSC5
  • BEC-1
  • DSPB1
  • LOST1
  • TUSC5
  • IFITMD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.78
transcription factor
0.6
cell type or tissue
0.59
tissue
0.56
microRNA
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.67   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.67   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
SGPL1
Tchem
Family:  Enzyme
Novelty:  0.00272574
p_int:  0.999997185
p_ni:  0.000002815
Score:  0.207
Data Source:  BioPlex,STRINGDB
TNPO2
Tbio
Novelty:  0.10454262
p_int:  0.998101407
p_ni:  0.001898592
p_wrong:  1e-9
Data Source:  BioPlex
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.980613323
p_ni:  0.019386676
Data Source:  BioPlex
RMND1
Tbio
Novelty:  0.06181833
p_int:  0.91038823
p_ni:  0.087414229
p_wrong:  0.00219754
Score:  0.179
Data Source:  BioPlex,STRINGDB
TNPO1
Tbio
Novelty:  0.01278619
p_int:  0.846854256
p_ni:  0.153145744
Score:  0.309
Data Source:  BioPlex,STRINGDB
BZW1
Tbio
Novelty:  0.11677238
p_int:  0.831368473
p_ni:  0.168631527
Score:  0.228
Data Source:  BioPlex,STRINGDB
PGGHG
Tbio
Family:  Enzyme
Novelty:  0.40196205
Score:  0.714
Data Source:  STRINGDB
PRRT1
Tbio
Novelty:  0.08707857
Score:  0.713
Data Source:  STRINGDB
BHLHA9
Tbio
Family:  TF
Novelty:  0.05522751
Score:  0.71
Data Source:  STRINGDB
ARMC7
Tdark
Novelty:  0.24695796
Score:  0.696
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.1
67.5
mean platelet volume
1
1
1
57.3
basophil count
1
1
0
2.3
44.2
mean corpuscular volume
1
1
1
37.6
reticulocyte measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
67.5
mean platelet volume
1
57.3
basophil count
0
2.3
44.2
mean corpuscular volume
1
37.6
reticulocyte measurement
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trafficking regulator of GLUT4 (SLC2A4) 1
VGNC:54189
747084
Mouse
MGI:3029307
237858
Rat
RGD:1307639
360576
Dog
tumor suppressor candidate 5 [Source:HGNC Symbol;Acc:HGNC:29592]
Horse
tumor suppressor candidate 5 [Source:HGNC Symbol;Acc:HGNC:29592]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trafficking regulator of GLUT4 (SLC2A4) 1
Mouse
Rat
Dog
tumor suppressor candidate 5 [Source:HGNC Symbol;Acc:HGNC:29592]
Horse
tumor suppressor candidate 5 [Source:HGNC Symbol;Acc:HGNC:29592]
Publication Statistics
PubMed Score 13.67
PubMed score by year
PubTator Score 43.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title