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Tbio
TRAPPC9
Trafficking protein particle complex subunit 9

Protein Summary
Description
Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. This gene encodes a protein that likely plays a role in NF-kappa-B signaling. Mutations in this gene have been associated with autosomal-recessive cognitive disability. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389328
  • ENSP00000373979
  • ENSG00000167632
  • ENST00000438773
  • ENSP00000405060
  • ENST00000648948
  • ENSP00000498020
  • ENST00000649035
  • ENSP00000497299

Symbol
  • KIAA1882
  • NIBP
  • T1
  • IBP
  • NIBP
  • MRT13
  • TRS120
  • IKBKBBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
transcription factor
0.85
disease perturbation
0.83
virus perturbation
0.68
cell type or tissue
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.69   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 108   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.69   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
TRAPPC5
Tdark
Novelty:  0.22558077
p_int:  0.999998491
p_ni:  0.000001509
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.999998458
p_ni:  0.000001542
Score:  0.998
Data Source:  BioPlex,STRINGDB
KANK4
Tdark
Novelty:  0.22871735
p_int:  0.999994448
p_ni:  0.000005552
Score:  0.788
Data Source:  BioPlex,STRINGDB
TRAPPC1
Tbio
Novelty:  0.09781468
p_int:  0.999991405
p_ni:  0.000008595
Score:  0.998
Data Source:  BioPlex,STRINGDB
BCL2L14
Tbio
Novelty:  0.03980069
p_int:  0.999982955
p_ni:  0.000017045
Score:  0.782
Data Source:  BioPlex,STRINGDB
STMN4
Tbio
Novelty:  0.00422625
p_int:  0.999967229
p_ni:  0.000032771
Score:  0.782
Data Source:  BioPlex,STRINGDB
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.999953782
p_ni:  0.000046218
Score:  0.384
Data Source:  BioPlex,STRINGDB
GATA2
Tbio
Family:  TF
Novelty:  0.00153967
p_int:  0.999883032
p_ni:  0.000116968
Score:  0.209
Data Source:  BioPlex,STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
p_int:  0.999796941
p_ni:  0.000203059
Score:  0.534
Data Source:  BioPlex,STRINGDB
CABS1
Tbio
Novelty:  0.10451682
p_int:  0.999767915
p_ni:  0.000232085
Score:  0.821
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
1
1
86.4
mathematical ability
2
2
2
58.9
cognitive function measurement
3
1
3
55.2
age at menarche
1
1
1
53.3
pulse pressure measurement
1
1
2
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
86.4
mathematical ability
2
58.9
cognitive function measurement
3
55.2
age at menarche
1
53.3
pulse pressure measurement
2
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 9
VGNC:775
464419
Mouse
MGI:1923760
76510
Dog
trafficking protein particle complex 9
VGNC:47788
482058
Horse
trafficking protein particle complex 9
VGNC:24478
100069518
Cow
trafficking protein particle complex 9
VGNC:36294
533451
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 9
Mouse
Dog
trafficking protein particle complex 9
Horse
trafficking protein particle complex 9
Cow
trafficking protein particle complex 9
Publication Statistics
PubMed Score 41.69
PubMed score by year
PubTator Score 123.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title