TRAPPC9
Trafficking protein particle complex subunit 9
Protein Summary
Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. This gene encodes a protein that likely plays a role in NF-kappa-B signaling. Mutations in this gene have been associated with autosomal-recessive cognitive disability. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
- ENST00000389328
- ENSP00000373979
- ENSG00000167632
- ENST00000438773
- ENSP00000405060
- ENST00000648948
- ENSP00000498020
- ENST00000649035
- ENSP00000497299
- KIAA1882
- NIBP
- T1
- IBP
- NIBP
- MRT13
- TRS120
- IKBKBBP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.92 | ||
transcription factor | 0.85 | ||
disease perturbation | 0.83 | ||
virus perturbation | 0.68 | ||
cell type or tissue | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 59.57 (req: < 5)
Gene RIFs: 25 (req: <= 3)
Antibodies: 108 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 59.57 (req: >= 5)
Gene RIFs: 25 (req: > 3)
Antibodies: 108 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0