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Tdark
TRAPPC8
Trafficking protein particle complex subunit 8

Protein Summary
Description
May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283351
  • ENSP00000283351
  • ENSG00000153339

Symbol
  • KIAA1012
  • GSG1
  • TRS85
  • HsT2706
  • KIAA1012
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
virus perturbation
0.94
histone modification site profile
0.91
microRNA
0.78
transcription factor binding site profile
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.12   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 6   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.12   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.99999945
p_ni:  5.5e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
TRAPPC1
Tbio
Novelty:  0.09781468
p_int:  0.999999317
p_ni:  6.83e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
TRAPPC5
Tdark
Novelty:  0.22558077
p_int:  0.9999986
p_ni:  0.000001397
p_wrong:  3e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRAPPC12
Tbio
Novelty:  0.09847363
p_int:  0.999989195
p_ni:  0.000010805
Score:  0.997
Data Source:  BioPlex,STRINGDB
TBC1D14
Tbio
Novelty:  0.25089884
p_int:  0.999456458
p_ni:  0.000543528
p_wrong:  1.4e-8
Score:  0.947
Data Source:  BioPlex,STRINGDB
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
p_int:  0.999244102
p_ni:  0.000755898
Score:  0.174
Data Source:  BioPlex,STRINGDB
SSRP1
Tbio
Family:  TF
Novelty:  0.0143993
p_int:  0.986091151
p_ni:  0.013908849
Score:  0.22
Data Source:  BioPlex,STRINGDB
MYL6
Tbio
Novelty:  0.00594485
p_int:  0.977987019
p_ni:  0.022012981
Data Source:  BioPlex
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.841191187
p_ni:  0.158808813
Score:  0.388
Data Source:  BioPlex,STRINGDB
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
p_int:  0.777426788
p_ni:  0.222573208
p_wrong:  4e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 8
VGNC:5215
468513
Macaque
trafficking protein particle complex 8
713645
Mouse
MGI:2443008
75964
Rat
RGD:1309102
291750
Dog
trafficking protein particle complex 8
VGNC:47787
480166
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 8
Macaque
trafficking protein particle complex 8
Mouse
Rat
Dog
trafficking protein particle complex 8
Publication Statistics
PubMed Score 13.12
PubMed score by year
PubTator Score 4.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title