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Tbio
TRAPPC6B
Trafficking protein particle complex subunit 6B

Protein Summary
Description
Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (PubMed:16025134, PubMed:16828797). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable). TRAPPC6B is a component of TRAPP complexes, which are tethering complexes involved in vesicle transport (Kummel et al., 2005 [PubMed 16025134]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330149
  • ENSP00000330289
  • ENSG00000182400
  • ENST00000347691
  • ENSP00000335171

Symbol
  • TPC6
  • NEDMEBA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.73
transcription factor binding site profile
0.72
kinase perturbation
0.66
tissue
0.62
microRNA
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.09   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.09   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
TRAPPC1
Tbio
Novelty:  0.09781468
p_int:  0.999999789
p_ni:  2.11e-7
Score:  0.996
Data Source:  BioPlex,STRINGDB
TRAPPC5
Tdark
Novelty:  0.22558077
p_int:  0.999999763
p_ni:  2.37e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.999996934
p_ni:  0.000003066
Score:  0.997
Data Source:  BioPlex,STRINGDB
BCL2L14
Tbio
Novelty:  0.03980069
p_int:  0.999962853
p_ni:  0.000037147
Score:  0.895
Data Source:  BioPlex,STRINGDB
STMN4
Tbio
Novelty:  0.00422625
p_int:  0.999950478
p_ni:  0.000049522
Score:  0.81
Data Source:  BioPlex,STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
p_int:  0.999682239
p_ni:  0.000317751
p_wrong:  1e-8
Score:  0.735
Data Source:  BioPlex,STRINGDB
TRAPPC12
Tbio
Novelty:  0.09847363
p_int:  0.999159084
p_ni:  0.000840916
Score:  0.99
Data Source:  BioPlex,STRINGDB
HOXB6
Tbio
Family:  TF
Novelty:  0.0176813
p_int:  0.996463092
p_ni:  0.003536902
p_wrong:  6e-9
Data Source:  BioPlex
CCDC102B
Tdark
Novelty:  0.28075569
p_int:  0.994009799
p_ni:  0.005990201
Data Source:  BioPlex
KCTD3
Tdark
Novelty:  0.33599775
p_int:  0.987526784
p_ni:  0.012430583
p_wrong:  0.000042634
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
9
5
8
7
97.5
seasonality measurement
1
1
0
7
53.7
self reported educational attainment
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
8
7
97.5
seasonality measurement
0
7
53.7
self reported educational attainment
1
35
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 6B
VGNC:3298
452874
Macaque
trafficking protein particle complex 6B
699000
Mouse
MGI:1925482
78232
Rat
RGD:1309325
299075
Dog
trafficking protein particle complex 6B
VGNC:47786
480296
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 6B
Macaque
trafficking protein particle complex 6B
Mouse
Rat
Dog
trafficking protein particle complex 6B
Publication Statistics
PubMed Score 6.09
PubMed score by year
PubTator Score 3.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title