Tbio TRAPPC12 Trafficking protein particle complex subunit 12

Protein Summary

Description

Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224).

Uniprot Accession IDs

• Q8WVT3
• B3KV01
• D6W4Y2
• Q8WVW1
• Q9Y395

Gene Name

• TRAPPC12

Ensembl ID

• ENST00000324266
• ENSP00000324318
• ENSG00000171853
• ENST00000382110
• ENSP00000371544

Symbol

• TRAMM
• TTC15
• PEBAS
• TTC15
• CGI-87
• TTC-15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.73
histone modification site profile	0.72
drug perturbation	0.71
cell line	0.69
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Trafficking Protein Particle Complex Subunit 12

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Trafficking Protein Particle Complex Subunit 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.79   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.79   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0