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Tbio
TRAM2
Translocating chain-associated membrane protein 2

Protein Summary
Description
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Required for proper insertion of the first transmembrane helix N-terminus of TM4SF20 into the ER lumen, may act as a ceramide sensor for regulated alternative translocation (RAT) (PubMed:27499293). TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000182527
  • ENSP00000182527
  • ENSG00000065308

Symbol
  • KIAA0057
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
transcription factor
0.78
transcription factor perturbation
0.68
microRNA
0.64
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.94   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.94   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.999945516
p_ni:  1.7e-8
p_wrong:  0.000054467
Score:  0.189
Data Source:  BioPlex,STRINGDB
DTL
Tbio
Novelty:  0.01659105
Score:  0.812
Data Source:  STRINGDB
SLN
Tbio
Novelty:  0.00504194
Score:  0.757
Data Source:  STRINGDB
PLN
Tbio
Novelty:  0.01615063
Score:  0.757
Data Source:  STRINGDB
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
Score:  0.756
Data Source:  STRINGDB
RRBP1
Tbio
Novelty:  0.01494613
Score:  0.714
Data Source:  STRINGDB
KLHL18
Tdark
Novelty:  0.52915213
Score:  0.703
Data Source:  STRINGDB
TMEM14A
Tbio
Novelty:  0.15995178
Score:  0.644
Data Source:  STRINGDB
ATP2A1
Tchem
Family:  Transporter
Novelty:  0.00355092
Score:  0.622
Data Source:  STRINGDB
SSR2
Tbio
Novelty:  0.01383689
Score:  0.621
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
91
low density lipoprotein cholesterol measurement
3
2
3
75.4
neutrophil count
2
2
2
68
platelet count
2
2
2
58.2
myeloid white cell count
1
1
1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
91
low density lipoprotein cholesterol measurement
3
75.4
neutrophil count
2
68
platelet count
2
58.2
myeloid white cell count
1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
translocation associated membrane protein 2
VGNC:12725
104001048
Macaque
translocation associated membrane protein 2
708636
Mouse
MGI:1924817
170829
Rat
RGD:1589151
100361830
Dog
translocation associated membrane protein 2
VGNC:49104
474936
Species
Name
OMA
EggNOG
Inparanoid
Chimp
translocation associated membrane protein 2
Macaque
translocation associated membrane protein 2
Mouse
Rat
Dog
translocation associated membrane protein 2
Publication Statistics
PubMed Score 11.94
PubMed score by year
PubTator Score 1.92
PubTator score by year
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Related Publications
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PMID
Year
Title