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Tbio
TRAK1
Trafficking kinesin-binding protein 1

Protein Summary
Description
Involved in the regulation of endosome-to-lysosome trafficking, including endocytic trafficking of EGF-EGFR complexes and GABA-A receptors (PubMed:18675823). Involved in mitochondrial motility. When O-glycosylated, abolishes mitochondrial motility. Crucial for recruiting OGT to the mitochondrial surface of neuronal processes (PubMed:24995978). TRAK1 and RHOT form an essential protein complex that links KIF5 to mitochondria for light chain-independent, anterograde transport of mitochondria (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327628
  • ENSP00000328998
  • ENSG00000182606
  • ENST00000341421
  • ENSP00000340702
  • ENST00000449246
  • ENSP00000410717

Symbol
  • KIAA1042
  • OIP106
  • MILT1
  • EIEE68
  • OIP106
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor perturbation
0.96
kinase perturbation
0.76
microRNA
0.69
cell line
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.7   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (133)
CARD19
Tbio
Family:  Enzyme
Novelty:  0.18215136
p_int:  0.99999997
p_ni:  3e-8
Data Source:  BioPlex
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.999999875
p_ni:  1.25e-7
Score:  0.386
Data Source:  BioPlex,STRINGDB
TRIM4
Tbio
Family:  Enzyme
Novelty:  0.11398363
p_int:  0.999990546
p_ni:  0.000009454
Data Source:  BioPlex
ZNF664
Tdark
Family:  TF
Novelty:  0.25879878
p_int:  0.999985442
p_ni:  0.000011243
p_wrong:  0.000003315
Data Source:  BioPlex
KIF5A
Tbio
Novelty:  0.01277095
p_int:  0.999929297
p_ni:  0.000070703
Score:  0.746
Data Source:  BioPlex,STRINGDB
RHOT1
Tbio
Family:  Enzyme
Novelty:  0.01411527
p_int:  0.999868417
p_ni:  0.000131583
Score:  0.932
Data Source:  BioPlex,STRINGDB
KLC2
Tbio
Novelty:  0.06284367
p_int:  0.99974639
p_ni:  0.00025361
Score:  0.392
Data Source:  BioPlex,STRINGDB
MTX3
Tdark
Novelty:  0.06082176
p_int:  0.999376585
p_ni:  0.000623415
Data Source:  BioPlex
CHCHD6
Tbio
Novelty:  0.12379343
p_int:  0.994674345
p_ni:  0.005325642
p_wrong:  1.3e-8
Data Source:  BioPlex
GOLGA2
Tbio
Novelty:  0.00544771
p_int:  0.990817708
p_ni:  0.009182291
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Oncogenic MAPK signaling
Reactome
Signaling by BRAF and RAF fusions
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Oncogenic MAPK signaling
Signaling by BRAF and RAF fusions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
7
6
9
93.4
2
2
0
1.4
93.1
diastolic blood pressure
1
1
1
67.3
comparative body size at age 10, self-reported
1
1
1
59.7
hemoglobin measurement
1
1
1
53.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
9
93.4
0
1.4
93.1
diastolic blood pressure
1
67.3
comparative body size at age 10, self-reported
1
59.7
hemoglobin measurement
1
53.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trafficking kinesin protein 1
VGNC:10446
460289
Macaque
trafficking kinesin protein 1
717773
Mouse
MGI:1914345
67095
Rat
RGD:1307844
316085
Dog
trafficking kinesin protein 1
VGNC:47773
485610
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trafficking kinesin protein 1
Macaque
trafficking kinesin protein 1
Mouse
Rat
Dog
trafficking kinesin protein 1
Publication Statistics
PubMed Score 27.70
PubMed score by year
PubTator Score 14.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title