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Tbio
TRAF7
E3 ubiquitin-protein ligase TRAF7

Protein Summary
Description
E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MEKK3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators. Induces apoptosis when overexpressed. Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326181
  • ENSP00000318944
  • ENSG00000131653

Symbol
  • RFWD1
  • RNF119
  • RFWD1
  • RNF119
  • CAFDADD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.91
transcription factor binding site profile
0.88
cell line
0.63
histone modification site profile
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.7   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.7   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (351)
WFIKKN1
Tbio
Novelty:  0.09604321
p_int:  0.999989913
p_ni:  0.000010087
Data Source:  BioPlex
CYTH4
Tbio
Novelty:  0.05783135
p_int:  0.999980979
p_ni:  0.000019021
Data Source:  BioPlex
OIP5
Tbio
Novelty:  0.02546471
p_int:  0.999979523
p_ni:  0.000019824
p_wrong:  6.54e-7
Data Source:  BioPlex
COL4A3BP
Tbio
Novelty:  0.00357203
p_int:  0.999978572
p_ni:  0.000021317
p_wrong:  1.1e-7
Score:  0.159
Data Source:  BioPlex,STRINGDB
MATN2
Tbio
Novelty:  0.08506252
p_int:  0.999892648
p_ni:  0.000107352
Score:  0.156
Data Source:  BioPlex,STRINGDB
RALYL
Tbio
Novelty:  0.20992411
p_int:  0.999732708
p_ni:  0.000267237
p_wrong:  5.5e-8
Data Source:  BioPlex
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.999558453
p_ni:  0.000441541
p_wrong:  6e-9
Data Source:  BioPlex
CORO1A
Tbio
Novelty:  0.00898925
p_int:  0.999450189
p_ni:  0.000549381
p_wrong:  4.31e-7
Score:  0.329
Data Source:  BioPlex,STRINGDB
IKBIP
Tbio
Family:  Enzyme
Novelty:  0.18707639
p_int:  0.998710114
p_ni:  0.001289885
p_wrong:  1e-9
Score:  0.154
Data Source:  BioPlex,STRINGDB
CD2BP2
Tbio
Novelty:  0.01440995
p_int:  0.998695627
p_ni:  0.001304356
p_wrong:  1.8e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
2
4
91
alkaline phosphatase measurement
2
2
1
6
91
serum gamma-glutamyl transferase measurement
2
2
2
90.8
BMI-adjusted waist circumference
2
4
5
81.1
BMI-adjusted hip circumference
2
5
7
75.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
91
alkaline phosphatase measurement
1
6
91
serum gamma-glutamyl transferase measurement
2
90.8
BMI-adjusted waist circumference
5
81.1
BMI-adjusted hip circumference
7
75.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor associated factor 7
VGNC:5946
467870
Macaque
TNF receptor associated factor 7
695415
Mouse
MGI:3042141
224619
Rat
RGD:1559653
360491
Dog
TNF receptor associated factor 7
VGNC:47770
609824
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor associated factor 7
Macaque
TNF receptor associated factor 7
Mouse
Rat
Dog
TNF receptor associated factor 7
Publication Statistics
PubMed Score 39.70
PubMed score by year
PubTator Score 14.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title