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Tbio
TRAF6
TNF receptor-associated factor 6

Protein Summary
Description
E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. The protein encoded by th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348124
  • ENSP00000337853
  • ENSG00000175104
  • ENST00000526995
  • ENSP00000433623

Symbol
  • RNF85
  • RNF85
  • MGC:3310
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
biological term
0.97
protein domain
0.97
molecular function
0.93


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 949.19   (req: < 5)
Gene RIFs: 238   (req: <= 3)
Antibodies: 509   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 949.19   (req: >= 5)
Gene RIFs: 238   (req: > 3)
Antibodies: 509   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 63
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (426)
TRAF1
Tbio
Novelty:  0.00526776
p_int:  0.999999917
p_ni:  8.3e-8
Score:  0.723
Data Source:  BioPlex,STRINGDB
IRAK2
Tbio
Family:  Kinase
Novelty:  0.01496024
p_int:  0.999999799
p_ni:  1.86e-7
p_wrong:  1.4e-8
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
WASHC3
Tdark
Novelty:  0.18307321
p_int:  0.999999534
p_ni:  4.66e-7
Data Source:  BioPlex
DEUP1
Tbio
Novelty:  0.13274391
p_int:  0.999972642
p_ni:  0.000027348
p_wrong:  1e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
EDA2R
Tbio
Novelty:  0.03463669
p_int:  0.999773863
p_ni:  0.00021294
p_wrong:  0.000013197
Score:  0.904
Data Source:  BioPlex,STRINGDB
COG6
Tbio
Novelty:  0.02874093
p_int:  0.999682343
p_ni:  0.000317573
p_wrong:  8.4e-8
Data Source:  BioPlex
SNAP29
Tbio
Novelty:  0.02009206
p_int:  0.999500433
p_ni:  0.000499558
p_wrong:  9e-9
Score:  0.15
Data Source:  BioPlex,STRINGDB
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.997166906
p_ni:  0.002823194
p_wrong:  0.0000099
Data Source:  BioPlex
PSMC5
Tbio
Family:  Enzyme
Novelty:  0.01634039
p_int:  0.996720455
p_ni:  0.003277692
p_wrong:  0.000001853
Data Source:  BioPlex
TRAF2
Tbio
Novelty:  0.00983658
p_int:  0.995559047
p_ni:  0.004426518
p_wrong:  0.000014435
Score:  0.983
Data Source:  BioPlex,STRINGDB
Pathways (206)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 66
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Cell death signalling via NRAGE, NRIF and NADE
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (74)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.7
56.2
red blood cell density measurement
1
1
1
56
mean corpuscular hemoglobin concentration
1
1
1
53.3
autosomal dominant compelling helio-ophthalmic outburst syndrome
1
1
0
1.1
49.5
BMI-adjusted waist-hip ratio
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
56.2
red blood cell density measurement
1
56
mean corpuscular hemoglobin concentration
1
53.3
autosomal dominant compelling helio-ophthalmic outburst syndrome
0
1.1
49.5
BMI-adjusted waist-hip ratio
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor associated factor 6
VGNC:3053
451702
Macaque
TNF receptor associated factor 6
716907
Mouse
MGI:108072
22034
Rat
RGD:1306853
311245
Dog
TNF receptor associated factor 6
VGNC:52058
100688110
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor associated factor 6
Macaque
TNF receptor associated factor 6
Mouse
Rat
Dog
TNF receptor associated factor 6
Publication Statistics
PubMed Score 949.19
PubMed score by year
PubTator Score 355.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title