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Tbio
TRAF2
TNF receptor-associated factor 2

Protein Summary
Description
Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from m ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247668
  • ENSP00000247668
  • ENSG00000127191

Symbol
  • TRAP3
  • TRAP
  • TRAP3
  • RNF117
  • MGC:45012
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
protein domain
0.99
molecular function
0.96
virus
0.89


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.18   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 691   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.18   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 691   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (311)
BIRC2
Tchem
Novelty:  0.00199701
p_int:  1
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
TRAF1
Tbio
Novelty:  0.00526776
p_int:  1
Score:  0.977
Data Source:  BioPlex,STRINGDB
TANK
Tbio
Novelty:  0.01003866
p_int:  0.999998343
p_ni:  5.63e-7
p_wrong:  0.000001094
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
LTBR
Tbio
Novelty:  0.003823
p_int:  0.999991837
p_ni:  0.000008163
Score:  0.954
Data Source:  BioPlex,Reactome,STRINGDB
FBXW7
Tbio
Novelty:  0.00180856
p_int:  0.999985823
p_ni:  0.000013965
p_wrong:  2.12e-7
Data Source:  BioPlex
TMEM102
Tbio
Novelty:  0.1239857
p_int:  0.999977684
p_ni:  0.000021638
p_wrong:  6.79e-7
Score:  0.193
Data Source:  BioPlex,STRINGDB
TBK1
Tchem
Family:  Kinase
Novelty:  0.00194753
p_int:  0.99996442
p_ni:  0.00003558
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
CXCL1
Tbio
Novelty:  0.00059123
p_int:  0.999680338
p_ni:  0.000319662
Data Source:  BioPlex
DIABLO
Tbio
Novelty:  0.0007851
p_int:  0.999386677
p_ni:  0.000613323
Score:  0.965
Data Source:  BioPlex,STRINGDB
RAB3IP
Tbio
Novelty:  0.04046982
p_int:  0.999167515
p_ni:  0.000482392
p_wrong:  0.000350093
Score:  0.179
Data Source:  BioPlex,STRINGDB
Pathways (163)
Apoptosis (R-HSA-109581)

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Find Similar Targets
Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
CASP8 activity is inhibited
Reactome
Caspase activation via Death Receptors in the presence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Apoptosis
CASP8 activity is inhibited
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (59)
Find Similar Targets
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
3
2
0
2.9
69.8
platelet crit
1
1
1
47.7
renal system measurement
1
1
1
37.5
heel bone mineral density
1
1
1
28.1
corneal topography
1
1
1
12.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
2.9
69.8
platelet crit
1
47.7
renal system measurement
1
37.5
heel bone mineral density
1
28.1
corneal topography
1
12.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TNF receptor associated factor 2
708391
Mouse
MGI:101835
22030
Rat
RGD:1310457
311786
Dog
TNF receptor associated factor 2
VGNC:47763
480673
Horse
TNF receptor associated factor 2
VGNC:24455
100068006
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TNF receptor associated factor 2
Mouse
Rat
Dog
TNF receptor associated factor 2
Horse
TNF receptor associated factor 2
Publication Statistics
PubMed Score 85.18
PubMed score by year
PubTator Score 375.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title