You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TRAC
T cell receptor alpha constant

Protein Summary
Description
Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of tr ...more
Uniprot Accession IDs
Gene Name
Symbol
  • TCRA
  • TRA
  • IMD7
  • TCRA
  • TRCA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
1
cell type or tissue
0.86
tissue
0.7
tissue sample
0.7
cellular component
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (45)
TAF7
Tbio
Novelty:  0.05316615
p_int:  0.999982888
p_ni:  0.00001711
p_wrong:  3e-9
Data Source:  BioPlex
ITPK1
Tbio
Family:  Kinase
Novelty:  0.02790263
p_int:  0.999150796
p_ni:  0.000750081
p_wrong:  0.000099123
Data Source:  BioPlex
OAF
Tbio
Novelty:  0.07130797
p_int:  0.995250201
p_ni:  0.004749782
p_wrong:  1.7e-8
Data Source:  BioPlex
EOGT
Tbio
Family:  Enzyme
Novelty:  0.08290891
p_int:  0.977366314
p_ni:  0.003922216
p_wrong:  0.01871147
Data Source:  BioPlex
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.930303542
p_ni:  0.069696458
Data Source:  BioPlex
CBWD1
Tbio
Novelty:  0.04321511
p_int:  0.868294758
p_ni:  0.131705242
Data Source:  BioPlex
BMP7
Tbio
Novelty:  0.00049424
p_int:  0.843124442
p_ni:  0.15686829
p_wrong:  0.000007268
Data Source:  BioPlex
COCH
Tbio
Novelty:  0.00819355
p_int:  0.832281194
p_ni:  0.167718806
Data Source:  BioPlex
MGAT5
Tbio
Family:  Enzyme
Novelty:  0.00707747
p_int:  0.826242287
p_ni:  0.173757649
p_wrong:  6.3e-8
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.758381677
p_ni:  0.241618323
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Costimulation by the CD28 family
Reactome
Downstream TCR signaling
Reactome
Generation of second messenger molecules
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Costimulation by the CD28 family
Downstream TCR signaling
Generation of second messenger molecules
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubTator Score 545.42
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title