Tbio TRA2A Transformer-2 protein homolog alpha

Protein Summary

Description

Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• Q13595
• B4DQI6
• B4DUA9
• E9PD75
• TRA-2 alpha

Gene Name

• TRA2A

Ensembl ID

• ENST00000297071
• ENSP00000297071
• ENSG00000164548
• ENST00000392502
• ENSP00000376290
• ENST00000538367
• ENSP00000441116
• ENST00000621813
• ENSP00000480822

Symbol

• AWMS1
• HSU53209

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.89
transcription factor binding site profile	0.84
ligand (protein) perturbation	0.83
drug perturbation	0.71
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Transformer-2 Protein Homolog Alpha

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Transformer-2 Protein Homolog Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.37   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 161   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.37   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (202)

Explore Interacting Targets

1 – 10 of 202

• See Interactions on String-DB

CLK2

Tchem

Family:  Kinase

Novelty:  0.13068449

p_int:  0.999989708

p_ni:  0.000010292

Score:  0.648

Data Source:  BioPlex,STRINGDB

CLK3

Tchem

Family:  Kinase

Novelty:  0.03466191

p_int:  0.999928388

p_ni:  0.000071612

Score:  0.648

Data Source:  BioPlex,STRINGDB

CLK1

Tchem

Family:  Kinase

Novelty:  0.00812732

p_int:  0.999867294

p_ni:  0.000132706

Score:  0.758

Data Source:  BioPlex,STRINGDB

SRSF12

Tbio

Novelty:  0.34992606

p_int:  0.999466666

p_ni:  0.000533236

p_wrong:  9.8e-8

Score:  0.558

Data Source:  BioPlex,STRINGDB

PABPC4L

Tdark

Novelty:  0.94386609

p_int:  0.999438897

p_ni:  0.000559081

p_wrong:  0.000002021

Score:  0.309

Data Source:  BioPlex,STRINGDB

SNRNP70

Tbio

Novelty:  0.00116631

p_int:  0.996954861

p_ni:  0.003045139

Score:  0.644

Data Source:  BioPlex,STRINGDB

RBBP6

Tbio

Family:  Enzyme

Novelty:  0.03147368

p_int:  0.996712355

p_ni:  0.003287645

Score:  0.546

Data Source:  BioPlex,STRINGDB

PPIG

Tchem

Family:  Enzyme

Novelty:  0.00014569

p_int:  0.99599019

p_ni:  0.003984247

p_wrong:  0.000025563

Score:  0.668

Data Source:  BioPlex,STRINGDB

TWNK

Tbio

Novelty:  0.00393371

p_int:  0.995024365

p_ni:  0.004975452

p_wrong:  1.83e-7

Data Source:  BioPlex

SRSF8

Tbio

Novelty:  0.16509556

p_int:  0.994890982

p_ni:  0.002968529

p_wrong:  0.002140489

Score:  0.757

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

Find Similar Targets

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Spliceosome	133 targets	path:hsa03040

Name	Explore in Pharos	Explore in Source
Spliceosome	133 targets	path:hsa03040

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (4)

Processes (2)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (17)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 17

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	3	6	7		82.6
body height	EFO_0004339	2	2	2		79.5
birth weight	EFO_0004344	5	3	5		75.7
neutrophil count	EFO_0004833	1	1	1		42.3
synophrys measurement	EFO_0007906	1	1	1		40.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 17

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted hip circumference	EFO_0008039	7		82.6
body height	EFO_0004339	2		79.5
birth weight	EFO_0004344	5		75.7
neutrophil count	EFO_0004833	1		42.3
synophrys measurement	EFO_0007906	1		40.7

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UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Complete proteome
Isopeptide bond
Methylation
mRNA processing
mRNA splicing
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
anthropometric measurement
birth weight
BMI-adjusted hip circumference
BMI-adjusted waist circumference
body height
body height at birth
HbA1c measurement
infant head circumference
leukocyte count

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	transformer 2 alpha homolog	VGNC:10054	463292
Macaque	transformer 2 alpha homolog		574247
Mouse	transformer 2 alpha	MGI:1933972	101214
Rat	transformer 2 alpha homolog	RGD:1562563	500116
Dog	transformer 2 alpha homolog	VGNC:47758	482358

Species	Name	OMA	EggNOG	Inparanoid
Chimp	transformer 2 alpha homolog
Macaque	transformer 2 alpha homolog
Mouse	transformer 2 alpha
Rat	transformer 2 alpha homolog
Dog	transformer 2 alpha homolog

Publication Statistics

PubMed Score 21.37

PubMed score by year

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PubTator Score 5.66

PubTator score by year

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Related Publications

Text Mined References (21)

GeneRif Annotations (6)

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10

0 of 0

PMID	Year	Title