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Tbio
TRA2A
Transformer-2 protein homolog alpha

Protein Summary
Description
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297071
  • ENSP00000297071
  • ENSG00000164548
  • ENST00000392502
  • ENSP00000376290
  • ENST00000538367
  • ENSP00000441116
  • ENST00000621813
  • ENSP00000480822

Symbol
  • AWMS1
  • HSU53209
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.89
transcription factor binding site profile
0.84
ligand (protein) perturbation
0.83
drug perturbation
0.71
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.37   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.37   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (202)
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
p_int:  0.999989708
p_ni:  0.000010292
Score:  0.648
Data Source:  BioPlex,STRINGDB
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.999928388
p_ni:  0.000071612
Score:  0.648
Data Source:  BioPlex,STRINGDB
CLK1
Tchem
Family:  Kinase
Novelty:  0.00812732
p_int:  0.999867294
p_ni:  0.000132706
Score:  0.758
Data Source:  BioPlex,STRINGDB
SRSF12
Tbio
Novelty:  0.34992606
p_int:  0.999466666
p_ni:  0.000533236
p_wrong:  9.8e-8
Score:  0.558
Data Source:  BioPlex,STRINGDB
PABPC4L
Tdark
Novelty:  0.94386609
p_int:  0.999438897
p_ni:  0.000559081
p_wrong:  0.000002021
Score:  0.309
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.996954861
p_ni:  0.003045139
Score:  0.644
Data Source:  BioPlex,STRINGDB
RBBP6
Tbio
Family:  Enzyme
Novelty:  0.03147368
p_int:  0.996712355
p_ni:  0.003287645
Score:  0.546
Data Source:  BioPlex,STRINGDB
PPIG
Tchem
Family:  Enzyme
Novelty:  0.00014569
p_int:  0.99599019
p_ni:  0.003984247
p_wrong:  0.000025563
Score:  0.668
Data Source:  BioPlex,STRINGDB
TWNK
Tbio
Novelty:  0.00393371
p_int:  0.995024365
p_ni:  0.004975452
p_wrong:  1.83e-7
Data Source:  BioPlex
SRSF8
Tbio
Novelty:  0.16509556
p_int:  0.994890982
p_ni:  0.002968529
p_wrong:  0.002140489
Score:  0.757
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
6
7
82.6
body height
2
2
2
79.5
birth weight
5
3
5
75.7
neutrophil count
1
1
1
42.3
synophrys measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
7
82.6
body height
2
79.5
birth weight
5
75.7
neutrophil count
1
42.3
synophrys measurement
1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transformer 2 alpha homolog
VGNC:10054
463292
Macaque
transformer 2 alpha homolog
574247
Mouse
MGI:1933972
101214
Rat
RGD:1562563
500116
Dog
transformer 2 alpha homolog
VGNC:47758
482358
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transformer 2 alpha homolog
Macaque
transformer 2 alpha homolog
Mouse
Rat
Dog
transformer 2 alpha homolog
Publication Statistics
PubMed Score 21.37
PubMed score by year
PubTator Score 5.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title