Tbio TPT1 Translationally-controlled tumor protein

Protein Summary

Description

Involved in calcium binding and microtubule stabilization. This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P13693
• B2R7E5
• Q6YLS2
• Q7Z4J4
• Q8TBK7
• Q96EE2
• Q9UC70
• TCTP

Gene Name

• TPT1

Ensembl ID

• ENST00000379055
• ENSP00000368344
• ENSG00000133112
• ENST00000379056
• ENSP00000368345
• ENST00000530705
• ENSP00000431872

Symbol

• HRF
• p02
• p23
• TCTP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
transcription factor binding site profile	0.94
virus perturbation	0.94
transcription factor	0.71

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Translationally-controlled Tumor Protein

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Non-motor Microtubule Binding Protein / Translationally-controlled Tumor Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1770.25   (req: < 5)

Gene RIFs: 107   (req: <= 3)

Antibodies: 501   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1770.25   (req: >= 5)

Gene RIFs: 107   (req: > 3)

Antibodies: 501   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0