Tbio TPST2 Protein-tyrosine sulfotransferase 2

Protein Summary

Description

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]

Uniprot Accession IDs

• O60704
• B3KQA7
• Q6FI98
• Q9H0V4

Gene Name

• TPST2

Ensembl ID

• ENST00000338754
• ENSP00000339813
• ENSG00000128294
• ENST00000398110
• ENSP00000381180
• ENST00000403880
• ENSP00000385192

Symbol

• TPST-2
• TANGO13B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
disease perturbation	0.9
small molecule perturbation	0.73
transcription factor	0.73
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transferase / Protein-tyrosine Sulfotransferase 2

DTO Classes

Protein / Enzyme / Transferase / Protein-tyrosine Sulfotransferase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.73   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 189   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.73   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0