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Tchem
TPSG1
Tryptase gamma

Protein Summary
Description
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by Ref ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234798
  • ENSP00000234798
  • ENSG00000116176

Symbol
  • PRSS31
  • TMT
  • TMT
  • trpA
  • PRSS31
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
protein domain
0.58
tissue
0.53
cell type or tissue
0.52
cellular component
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.82   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.82   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (5)
HCN2
Tclin
Family:  IC
Novelty:  0.02421034
Score:  0.675
Data Source:  STRINGDB
CPA3
Tchem
Family:  Enzyme
Novelty:  0.01537101
Score:  0.516
Data Source:  STRINGDB
CPA4
Tchem
Family:  Enzyme
Novelty:  0.01439845
Score:  0.506
Data Source:  STRINGDB
NMU
Tbio
Novelty:  0.00326109
Score:  0.473
Data Source:  STRINGDB
POTEI
Tdark
Novelty:  0.41311202
Score:  0.416
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
4
90.1
blood protein measurement
2
2
3
81.2
educational attainment
1
2
2
72.4
self reported educational attainment
1
1
1
63.7
neutrophil count
3
2
3
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
90.1
blood protein measurement
3
81.2
educational attainment
2
72.4
self reported educational attainment
1
63.7
neutrophil count
3
61.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
tryptase gamma 1
100425751
Mouse
MGI:1349391
26945
Rat
RGD:631355
302990
Horse
tryptase gamma 1
VGNC:24447
100067538
Species
Name
OMA
EggNOG
Inparanoid
Macaque
tryptase gamma 1
Mouse
Rat
Horse
tryptase gamma 1
Publication Statistics
PubMed Score 41.82
PubMed score by year
PubTator Score 78.88
PubTator score by year
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Related Publications
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PMID
Year
Title